biostudies-literatureBauer MAustrian Science Fund FWF1326-31https://www.ebi.ac.uk/biostudies/studies/S-EPMC4189097biostudies-literatureUnknown83(15)<h4>Objectives</h4>To study the functional activity of the multidrug efflux transporter P-glycoprotein (Pgp) at the blood-brain barrier of patients with temporal lobe epilepsy using (R)-[(11)C]verapamil (VPM)-PET before and after temporal lobe surgery to assess whether postoperative changes in seizure frequency and antiepileptic drug load are associated with changes in Pgp function.<h4>Methods</h4>Seven patients with drug-resistant temporal lobe epilepsy underwent VPM-PET scans pre- and postsurgery. Patients were followed up for a median of 6 years (range 4-7) after surgery. Pgp immunoreactivity in surgically resected hippocampal specimens was determined with immunohistochemistry.<h4>Results</h4>Optimal surgical outcome, defined as seizure freedom and withdrawal of antiepileptic drugs, wasNeurologyIn vivo P-glycoprotein function before and after epilepsy surgery.PMC4189097F 3513KLI 139F 3513-B20Liu JMuller MZeitlinger MAsselin MCSisodiya SMLanger OBauer MMitterhauser MWadsak WHainfellner JAPataraia EKarch RKoepp MJfalseIn vivo P-glycoprotein function before and after epilepsy surgery.<h4>Objectives</h4>To study the functional activity of the multidrug efflux transporter P-glycoprotein (Pgp) at the blood-brain barrier of patients with temporal lobe epilepsy using (R)-[(11)C]verapamil (VPM)-PET before and after temporal lobe surgery to assess whether postoperative changes in seizure frequency and antiepileptic drug load are associated with changes in Pgp function.<h4>Methods</h4>Seven patients with drug-resistant temporal lobe epilepsy underwent VPM-PET scans pre- and postsurgery. Patients were followed up for a median of 6 years (range 4-7) after surgery. Pgp immunoreactivity in surgically resected hippocampal specimens was determined with immunohistochemistry.<h4>Results</h4>Optimal surgical outcome, defined as seizure freedom and withdrawal of antiepileptic drugs, was2014-01-01T00:00:00Z2014 Oct2025-04-05T00:20:49.311Z2019-03-27T01:37:11ZS-EPMC41890972518685810.1212/WNL.0000000000000858