{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Huang CJ"],"pubmed_abstract":["<h4>Background</h4>Hypoxia inducible factor 1α (HIF-1α) is a stress-responsive transcription factor to hypoxia and its expression is correlated to tumor progression and angiogenesis. Several single nucleotide polymorphisms (SNPs) of HIF-1α gene in the oxygen-dependent degradation (ODD) domain was reportedly associated with increased HIF-1α activity.<h4>Results</h4>In this study, we focused on the relationship between SNP 1772 C > T (rs11549465) of HIF-1α gene and its breast cancer risk, as well as its correlation with HIF-1α expression and tumor angiogenesis. Ninety six breast cancer patients and 120 age-matched controls were enrolled. We found that 1772 T allele of HIF-1α gene was associated with increased breast cancer risk (adjusted OR = 14.51; 95% CI: 6.74-31.24). This SNP was not asso"],"journal":["Cancer cell international"],"pagination":["87"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4190286"],"repository":["biostudies-literature"],"pubmed_title":["SNP 1772 C > T of HIF-1α gene associates with breast cancer risk in a Taiwanese population."],"pmcid":["PMC4190286"],"pubmed_authors":["Lian SL","Yang YH","Chang HW","Hou MF","Lin SF","Chai CY","Huang CJ"],"additional_accession":[]},"is_claimable":false,"name":"SNP 1772 C > T of HIF-1α gene associates with breast cancer risk in a Taiwanese population.","description":"<h4>Background</h4>Hypoxia inducible factor 1α (HIF-1α) is a stress-responsive transcription factor to hypoxia and its expression is correlated to tumor progression and angiogenesis. Several single nucleotide polymorphisms (SNPs) of HIF-1α gene in the oxygen-dependent degradation (ODD) domain was reportedly associated with increased HIF-1α activity.<h4>Results</h4>In this study, we focused on the relationship between SNP 1772 C > T (rs11549465) of HIF-1α gene and its breast cancer risk, as well as its correlation with HIF-1α expression and tumor angiogenesis. Ninety six breast cancer patients and 120 age-matched controls were enrolled. We found that 1772 T allele of HIF-1α gene was associated with increased breast cancer risk (adjusted OR = 14.51; 95% CI: 6.74-31.24). This SNP was not asso","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2025-04-18T16:59:01.649Z","creation":"2019-03-27T01:37:15Z"},"accession":"S-EPMC4190286","cross_references":{"pubmed":["25302049"],"doi":["10.1186/s12935-014-0087-7"]}}