biostudies-literatureUnknown14(1)Huang CJ<h4>Background</h4>Hypoxia inducible factor 1α (HIF-1α) is a stress-responsive transcription factor to hypoxia and its expression is correlated to tumor progression and angiogenesis. Several single nucleotide polymorphisms (SNPs) of HIF-1α gene in the oxygen-dependent degradation (ODD) domain was reportedly associated with increased HIF-1α activity.<h4>Results</h4>In this study, we focused on the relationship between SNP 1772 C > T (rs11549465) of HIF-1α gene and its breast cancer risk, as well as its correlation with HIF-1α expression and tumor angiogenesis. Ninety six breast cancer patients and 120 age-matched controls were enrolled. We found that 1772 T allele of HIF-1α gene was associated with increased breast cancer risk (adjusted OR = 14.51; 95% CI: 6.74-31.24). This SNP was not assoCancer cell international87https://www.ebi.ac.uk/biostudies/studies/S-EPMC4190286biostudies-literatureSNP 1772 C > T of HIF-1α gene associates with breast cancer risk in a Taiwanese population.PMC4190286Lian SLYang YHChang HWHou MFLin SFChai CYHuang CJfalseSNP 1772 C > T of HIF-1α gene associates with breast cancer risk in a Taiwanese population.<h4>Background</h4>Hypoxia inducible factor 1α (HIF-1α) is a stress-responsive transcription factor to hypoxia and its expression is correlated to tumor progression and angiogenesis. Several single nucleotide polymorphisms (SNPs) of HIF-1α gene in the oxygen-dependent degradation (ODD) domain was reportedly associated with increased HIF-1α activity.<h4>Results</h4>In this study, we focused on the relationship between SNP 1772 C > T (rs11549465) of HIF-1α gene and its breast cancer risk, as well as its correlation with HIF-1α expression and tumor angiogenesis. Ninety six breast cancer patients and 120 age-matched controls were enrolled. We found that 1772 T allele of HIF-1α gene was associated with increased breast cancer risk (adjusted OR = 14.51; 95% CI: 6.74-31.24). This SNP was not asso2014-01-01T00:00:00Z20142025-04-18T16:59:01.649Z2019-03-27T01:37:15ZS-EPMC41902862530204910.1186/s12935-014-0087-7