biostudies-literatureLee ENIAAA NIH HHS154https://www.ebi.ac.uk/biostudies/studies/S-EPMC4196140biostudies-literatureUnknown14<h4>Background</h4>Exposure to perinatal anxiety affects disease susceptibility in offspring but studies on the association between perinatal anxiety and gene polymorphisms are lacking. This study aimed to elucidate the interaction between perinatal anxiety and polymorphisms in antioxidant defense and innate immunity genes on the development of respiratory tract infections (RTIs) during early infancy.<h4>Methods</h4>Trait anxiety levels in 440 women were assessed by the State-Trait Anxiety Inventory during late gestation. The occurrence of RTIs, including bronchiolitis, during the first year of life was assessed by parent-reported doctor diagnosis. Polymorphisms in glutathione S-transferase P-1 (GSTP1, rs1695) and CD14 (rs2569190) were genotyped using the TaqMan assay. Copy number variatioBMC pulmonary medicineThe effect of perinatal anxiety on bronchiolitis is influenced by polymorphisms in ROS-related genes.PMC4196140K01 AA021511Shin YJShin YHKim EJKim KWAhn KMLee ELee JSKim HYKang MJPark JSeo JHChang HYKim BJCOCOA study groupKwon JWWon HSLee KSYu HSLee SYKwon JYJung YHYang SIChoi IASuh DIChoi SJLee KJKim HBKeyes KMHong SJfalseThe effect of perinatal anxiety on bronchiolitis is influenced by polymorphisms in ROS-related genes.<h4>Background</h4>Exposure to perinatal anxiety affects disease susceptibility in offspring but studies on the association between perinatal anxiety and gene polymorphisms are lacking. This study aimed to elucidate the interaction between perinatal anxiety and polymorphisms in antioxidant defense and innate immunity genes on the development of respiratory tract infections (RTIs) during early infancy.<h4>Methods</h4>Trait anxiety levels in 440 women were assessed by the State-Trait Anxiety Inventory during late gestation. The occurrence of RTIs, including bronchiolitis, during the first year of life was assessed by parent-reported doctor diagnosis. Polymorphisms in glutathione S-transferase P-1 (GSTP1, rs1695) and CD14 (rs2569190) were genotyped using the TaqMan assay. Copy number variatio2014-01-01T00:00:00Z2014 Sep2026-04-29T10:44:16.41Z2019-03-27T01:37:32ZS-EPMC41961402526384010.1186/1471-2466-14-154