biostudies-literatureUnknown15(6)Frei dit Frey N<h4>Background</h4>Mitogen-activated protein kinases (MAPKs) are key regulators of immune responses in animals and plants. In Arabidopsis, perception of microbe-associated molecular patterns (MAMPs) activates the MAPKs MPK3, MPK4 and MPK6. Increasing information depicts the molecular events activated by MAMPs in plants, but the specific and cooperative contributions of the MAPKs in these signalling events are largely unclear.<h4>Results</h4>In this work, we analyse the behaviour of MPK3, MPK4 and MPK6 mutants in early and late immune responses triggered by the MAMP flg22 from bacterial flagellin. A genome-wide transcriptome analysis reveals that 36% of the flg22-upregulated genes and 68% of the flg22-downregulated genes are affected in at least one MAPK mutant. So far MPK4 was considered aGenome biologyR87https://www.ebi.ac.uk/biostudies/studies/S-EPMC4197828biostudies-literatureFunctional analysis of Arabidopsis immune-related MAPKs uncovers a role for MPK3 as negative regulator of inducible defences.PMC4197828Aubourg SGarmier MGarcia AVZaag RBalzergue Sde Tauzia-Moreau MLFrei dit Frey NHirt HBueso EColcombet JMartin-Magniette MLPateyron SBrunaud VBigeard JfalseFunctional analysis of Arabidopsis immune-related MAPKs uncovers a role for MPK3 as negative regulator of inducible defences.<h4>Background</h4>Mitogen-activated protein kinases (MAPKs) are key regulators of immune responses in animals and plants. In Arabidopsis, perception of microbe-associated molecular patterns (MAMPs) activates the MAPKs MPK3, MPK4 and MPK6. Increasing information depicts the molecular events activated by MAMPs in plants, but the specific and cooperative contributions of the MAPKs in these signalling events are largely unclear.<h4>Results</h4>In this work, we analyse the behaviour of MPK3, MPK4 and MPK6 mutants in early and late immune responses triggered by the MAMP flg22 from bacterial flagellin. A genome-wide transcriptome analysis reveals that 36% of the flg22-upregulated genes and 68% of the flg22-downregulated genes are affected in at least one MAPK mutant. So far MPK4 was considered a2014-01-01T00:00:00Z2014 Jun2026-04-17T15:08:03.33Z2026-04-07T14:24:16.55ZS-EPMC41978282498008010.1186/gb-2014-15-6-r87