{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Buddhari D"],"funding":["NIAID NIH HHS","NIGMS NIH HHS"],"pagination":["e3230"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4199527"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(10)"],"pubmed_abstract":["<h4>Background</h4>Long-term homologous and temporary heterologous protection from dengue virus (DENV) infection may be mediated by neutralizing antibodies. However, neutralizing antibody titers (NTs) have not been clearly associated with protection from infection.<h4>Methodology/principal findings</h4>Data from two geographic cluster studies conducted in Kamphaeng Phet, Thailand were used for this analysis. In the first study (2004-2007), cluster investigations of 100-meter radius were triggered by DENV-infected index cases from a concurrent prospective cohort. Subjects between 6 months and 15 years old were evaluated for DENV infection at days 0 and 15 by DENV PCR and IgM ELISA. In the second study (2009-2012), clusters of 200-meter radius were triggered by DENV-infected index cases admi"],"journal":["PLoS neglected tropical diseases"],"pubmed_title":["Dengue virus neutralizing antibody levels associated with protection from infection in thai cluster studies."],"pmcid":["PMC4199527"],"funding_grant_id":["R01 GM083224","P01 AI34533","P01 AI034533"],"pubmed_authors":["Endy TP","Thaisomboonsuk B","Scott TW","Nisalak A","Khuntirat B","Rothman AL","Yoon IK","Srikiatkhachorn A","Klungthong C","Buddhari D","Fernandez S","Jarman RG","Thomas SJ","Aldstadt J"],"additional_accession":[]},"is_claimable":false,"name":"Dengue virus neutralizing antibody levels associated with protection from infection in thai cluster studies.","description":"<h4>Background</h4>Long-term homologous and temporary heterologous protection from dengue virus (DENV) infection may be mediated by neutralizing antibodies. However, neutralizing antibody titers (NTs) have not been clearly associated with protection from infection.<h4>Methodology/principal findings</h4>Data from two geographic cluster studies conducted in Kamphaeng Phet, Thailand were used for this analysis. In the first study (2004-2007), cluster investigations of 100-meter radius were triggered by DENV-infected index cases from a concurrent prospective cohort. Subjects between 6 months and 15 years old were evaluated for DENV infection at days 0 and 15 by DENV PCR and IgM ELISA. In the second study (2009-2012), clusters of 200-meter radius were triggered by DENV-infected index cases admi","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Oct","modification":"2025-04-19T23:12:43.539Z","creation":"2019-03-27T01:37:46Z"},"accession":"S-EPMC4199527","cross_references":{"pubmed":["25329173"],"doi":["10.1371/journal.pntd.0003230"]}}