{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Choi M"],"funding":["NIMH NIH HHS"],"pagination":["e109253"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4207676"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(10)"],"pubmed_abstract":["Functional consequences to which vertebrate GATA transcription factors contribute in the adult brain remain largely an open question. The present study examines how human GATA-1 and GATA-2 (hGATA-1 and hGATA-2) are linked to neuronal differentiation and depressive behaviors in rats. We investigated the effects of adeno-associated viral expression of hGATA-1 and hGATA-2 (AAV-hGATA1 and AAV-hGATA2) in the dentate gyrus (DG) of the dorsal hippocampus on dendrite branching and spine number. We also examined the influence of AAV-hGATA1 and AAV-hGATA2 infusions into the dorsal hippocampus on rodent behavior in models of depression. Viral expression of hGATA-1 and hGATA-2 cDNA in rat hippocampal neurons impaired dendritic outgrowth and spine formation. Moreover, viral-mediated expression of hGATA"],"journal":["PloS one"],"pubmed_title":["Overexpression of human GATA-1 and GATA-2 interferes with spine formation and produces depressive behavior in rats."],"pmcid":["PMC4207676"],"funding_grant_id":["R01 MH093897","R01 MH105910"],"pubmed_authors":["Ko SY","Chae SY","Kang HJ","Lee SH","Duman RS","Choi M","Wang SE","Kim YS","Son H"],"additional_accession":[]},"is_claimable":false,"name":"Overexpression of human GATA-1 and GATA-2 interferes with spine formation and produces depressive behavior in rats.","description":"Functional consequences to which vertebrate GATA transcription factors contribute in the adult brain remain largely an open question. The present study examines how human GATA-1 and GATA-2 (hGATA-1 and hGATA-2) are linked to neuronal differentiation and depressive behaviors in rats. We investigated the effects of adeno-associated viral expression of hGATA-1 and hGATA-2 (AAV-hGATA1 and AAV-hGATA2) in the dentate gyrus (DG) of the dorsal hippocampus on dendrite branching and spine number. We also examined the influence of AAV-hGATA1 and AAV-hGATA2 infusions into the dorsal hippocampus on rodent behavior in models of depression. Viral expression of hGATA-1 and hGATA-2 cDNA in rat hippocampal neurons impaired dendritic outgrowth and spine formation. Moreover, viral-mediated expression of hGATA","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2025-04-18T16:19:15.969Z","creation":"2019-03-26T23:28:51Z"},"accession":"S-EPMC4207676","cross_references":{"pubmed":["25340772"],"doi":["10.1371/journal.pone.0109253"]}}