{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Folco EJ"],"funding":["NHLBI NIH HHS"],"pagination":["875-83"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4209192"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["115(10)"],"pubmed_abstract":["<h4>Rationale</h4>Inflammation drives atherogenesis. Animal and human studies have implicated interleukin-1β (IL-1β) in this disease. Moderate hypoxia, a condition that prevails in the atherosclerotic plaque, may conspire with inflammation and contribute to the evolution and complications of atherosclerosis through mechanisms that remain incompletely understood.<h4>Objective</h4>This study investigated the links between hypoxia and inflammation by testing the hypothesis that moderate hypoxia modulates IL-1β production in activated human macrophages.<h4>Methods and results</h4>Our results demonstrated that hypoxia enhances pro-IL-1β protein, but not mRNA, expression in lipopolysaccharide-stimulated human macrophages. We show that hypoxia limits the selective targeting of pro-IL-1β to autoph"],"journal":["Circulation research"],"pubmed_title":["Moderate hypoxia potentiates interleukin-1β production in activated human macrophages."],"pmcid":["PMC4209192"],"funding_grant_id":["P01 HL048743","R01 HL080472"],"pubmed_authors":["Folco EJ","Quillard T","Libby P","Sukhova GK"],"additional_accession":[]},"is_claimable":false,"name":"Moderate hypoxia potentiates interleukin-1β production in activated human macrophages.","description":"<h4>Rationale</h4>Inflammation drives atherogenesis. Animal and human studies have implicated interleukin-1β (IL-1β) in this disease. Moderate hypoxia, a condition that prevails in the atherosclerotic plaque, may conspire with inflammation and contribute to the evolution and complications of atherosclerosis through mechanisms that remain incompletely understood.<h4>Objective</h4>This study investigated the links between hypoxia and inflammation by testing the hypothesis that moderate hypoxia modulates IL-1β production in activated human macrophages.<h4>Methods and results</h4>Our results demonstrated that hypoxia enhances pro-IL-1β protein, but not mRNA, expression in lipopolysaccharide-stimulated human macrophages. We show that hypoxia limits the selective targeting of pro-IL-1β to autoph","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Oct","modification":"2025-04-05T09:46:26.794Z","creation":"2019-03-27T01:38:20Z"},"accession":"S-EPMC4209192","cross_references":{"pubmed":["25185259"],"doi":["10.1161/CIRCRESAHA.115.304437","10.1161/circresaha.115.304437"]}}