{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lu M"],"funding":["NCI NIH HHS"],"pagination":["E4165-74"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4210007"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["111(40)"],"pubmed_abstract":["Development of effective strategies to mobilize the immune system as a therapeutic modality in cancer necessitates a better understanding of the contribution of the tumor microenvironment to the complex interplay between cancer cells and the immune response. Recently, effort has been directed at unraveling the functional role of exosomes and their cargo of messengers in this interplay. Exosomes are small vesicles (30-200 nm) that mediate local and long-range communication through the horizontal transfer of information, such as combinations of proteins, mRNAs and microRNAs. Here, we develop a tractable theoretical framework to study the putative role of exosome-mediated cell-cell communication in the cancer-immunity interplay. We reduce the complex interplay into a generic model whose three"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Modeling putative therapeutic implications of exosome exchange between tumor and immune cells."],"pmcid":["PMC4210007"],"funding_grant_id":["P30 CA016672"],"pubmed_authors":["Hanash SM","Lu M","Ben-Jacob E","Huang B","Onuchic JN"],"additional_accession":[]},"is_claimable":false,"name":"Modeling putative therapeutic implications of exosome exchange between tumor and immune cells.","description":"Development of effective strategies to mobilize the immune system as a therapeutic modality in cancer necessitates a better understanding of the contribution of the tumor microenvironment to the complex interplay between cancer cells and the immune response. Recently, effort has been directed at unraveling the functional role of exosomes and their cargo of messengers in this interplay. Exosomes are small vesicles (30-200 nm) that mediate local and long-range communication through the horizontal transfer of information, such as combinations of proteins, mRNAs and microRNAs. Here, we develop a tractable theoretical framework to study the putative role of exosome-mediated cell-cell communication in the cancer-immunity interplay. We reduce the complex interplay into a generic model whose three","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Oct","modification":"2025-04-22T21:13:33.776Z","creation":"2019-03-27T01:38:22Z"},"accession":"S-EPMC4210007","cross_references":{"pubmed":["25246552"],"doi":["10.1073/pnas.1416745111"]}}