{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cherney AH"],"funding":["Camille and Henry Dreyfus Foundation","American Cancer Society","Amgen","DuPont","Alfred P. Sloan Foundation","National Institute of General Medical Sciences","Eli Lilly and Company","NIGMS NIH HHS","Division of Graduate Education","Novartis"],"pagination":["14365-8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4210114"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["136(41)"],"pubmed_abstract":["A Ni-catalyzed asymmetric reductive cross-coupling between vinyl bromides and benzyl chlorides has been developed. This method provides direct access to enantioenriched products bearing aryl-substituted tertiary allylic stereogenic centers from simple, stable starting materials. A broad substrate scope is achieved under mild reaction conditions that preclude the pregeneration of organometallic reagents and the regioselectivity issues commonly associated with asymmetric allylic arylation."],"journal":["Journal of the American Chemical Society"],"pubmed_title":["Nickel-catalyzed asymmetric reductive cross-coupling between vinyl and benzyl electrophiles."],"pmcid":["PMC4210114"],"funding_grant_id":["R01 GM111805","DGE-1144469","GM111805-01"],"pubmed_authors":["Reisman SE","Cherney AH"],"additional_accession":[]},"is_claimable":false,"name":"Nickel-catalyzed asymmetric reductive cross-coupling between vinyl and benzyl electrophiles.","description":"A Ni-catalyzed asymmetric reductive cross-coupling between vinyl bromides and benzyl chlorides has been developed. This method provides direct access to enantioenriched products bearing aryl-substituted tertiary allylic stereogenic centers from simple, stable starting materials. A broad substrate scope is achieved under mild reaction conditions that preclude the pregeneration of organometallic reagents and the regioselectivity issues commonly associated with asymmetric allylic arylation.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Oct","modification":"2025-04-22T21:09:46.878Z","creation":"2019-03-27T01:38:23Z"},"accession":"S-EPMC4210114","cross_references":{"pubmed":["25245492"],"doi":["10.1021/ja508067c"]}}