biostudies-literatureCherney AHCamille and Henry Dreyfus FoundationAmerican Cancer SocietyAmgenDuPontAlfred P. Sloan FoundationNational Institute of General Medical SciencesEli Lilly and CompanyNIGMS NIH HHSDivision of Graduate EducationNovartis14365-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC4210114biostudies-literatureUnknown136(41)A Ni-catalyzed asymmetric reductive cross-coupling between vinyl bromides and benzyl chlorides has been developed. This method provides direct access to enantioenriched products bearing aryl-substituted tertiary allylic stereogenic centers from simple, stable starting materials. A broad substrate scope is achieved under mild reaction conditions that preclude the pregeneration of organometallic reagents and the regioselectivity issues commonly associated with asymmetric allylic arylation.Journal of the American Chemical SocietyNickel-catalyzed asymmetric reductive cross-coupling between vinyl and benzyl electrophiles.PMC4210114R01 GM111805DGE-1144469GM111805-01Reisman SECherney AHfalseNickel-catalyzed asymmetric reductive cross-coupling between vinyl and benzyl electrophiles.A Ni-catalyzed asymmetric reductive cross-coupling between vinyl bromides and benzyl chlorides has been developed. This method provides direct access to enantioenriched products bearing aryl-substituted tertiary allylic stereogenic centers from simple, stable starting materials. A broad substrate scope is achieved under mild reaction conditions that preclude the pregeneration of organometallic reagents and the regioselectivity issues commonly associated with asymmetric allylic arylation.2014-01-01T00:00:00Z2014 Oct2025-04-22T21:09:46.878Z2019-03-27T01:38:23ZS-EPMC42101142524549210.1021/ja508067c