{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Holmes MV"],"funding":["Economic and Social Research Council","British Heart Foundation","NHLBI NIH HHS","Medical Research Council","National Institute for Health Research (NIHR)"],"pagination":["144-50"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4212409"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(2)"],"pubmed_abstract":["<h4>Background</h4>Secretory phospholipase A2 (sPLA2) enzymes are considered to play a role in atherosclerosis. sPLA2 activity encompasses several sPLA2 isoenzymes, including sPLA2-V. Although observational studies show a strong association between elevated sPLA2 activity and CHD, no assay to measure sPLA2-V levels exists, and the only evidence linking the sPLA2-V isoform to atherosclerosis progression comes from animal studies. In the absence of an assay that directly quantifies sPLA2-V levels, we used PLA2G5 mRNA levels in a novel, modified Mendelian randomization approach to investigate the hypothesized causal role of sPLA2-V in coronary heart disease (CHD) pathogenesis.<h4>Methods and results</h4>Using data from the Advanced Study of Aortic Pathology, we identified the single-nucleotid"],"journal":["Circulation. Cardiovascular genetics"],"pubmed_title":["Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels."],"pmcid":["PMC4212409"],"funding_grant_id":["RG/08/008/25291","G1000143","P01 HL-49058","ES/K005146/1","R01 HL-105924","NF-SI-0512-10114","P01 HL-62426","R01 HL-91056","G0802432","RG/10/12/28456","MR/K013351/1","R01 HL-81680","ES/J023299/1","P01 HL-077101","R01 HL036310","R01 HL-64035","MR/K006584/1","G0401527","T32 HL-07692","ES/H029745/1","FS/13/6/29977","RG/10/001/27643"],"pubmed_authors":["Matthai W","Psaty BM","Franco-Cereceda A","Siscovick DS","Rice K","Stark K","Scharnagl H","Melander O","Wilensky R","Go A","Asselbergs FW","Gudnason V","Bruse P","Hoffmann MM","Schreiber S","Hengstenberg C","Laaksonen R","Lieb W","Uitterlinden A","Stewart AF","Gabriel SB","Keating BJ","Munzel T","Dehghan A","Risch N","Schwartz SM","Kathiresan S","Aherrahrou Z","Devaney J","Morrison A","Knowles J","Tomaschitz A","Nelson CP","Lindsay JM","Klopp N","Hall AS","Sidney S","Konig IR","Tiret L","Levy D","Gretarsdottir S","Cupples L","Fischer M","Proust C","Preuss M","Holm H","Thorsteinsdottir U","Voight BF","Zeller T","Boekholdt SM","Altshuler D","Waksman R","Erdmann J","Blankenberg S","Salomaa V","Marciante K","Bohm BO","Jarinova O","Ziegler A","Khaw KT","Smith AJ","Tang H","Schillert A","Deloukas P","Whitteman J","Kong A","Pichard AD","Qu L","Wells GA","Hofman A","Exeter HJ","McPherson R","Hall A","CARDIoGRAM Consortium","Grammer TB","Dobnig H","Iribarren C","Ramachandran V","Hlatky M","Taylor KD","Wagner AK","Reiner AP","Loley C","Donnell CJ","Balmforth AJ","Winkler K","Schnabel R","Nicaud V","Grosshennig A","Cooper JA","Peltonen L","Kleber M","Peters A","Mallat Z","Rotter JI","Dandona S","Braund PS","Thorleifsson G","Roberts R","Wright BJ","Reilly MP","Stefansson K","Musunuru K","Andersen K","Medack A","Boerwinkle E","Van't Hooft F","Hofker M","Li KW","Gulcher JR","Demissie-Banjaw S","Absher D","Nahrstedt J","Perret C","Folsom A","Willenborg C","Glazer N","Schunkert H","Talmud PJ","Meitinger T","Meinitzer A","Renner W","Pilz S","Sinning C","Chen L","Onland-Moret NC","Meisinger C","Li M","Satler L","Walker MC","Cambien F","Samani NJ","Myers R","Holmes MV","Volcik K","Mooser V","Thorgeirsson G","Assimes TL","Guiducci C","Eriksson P","Boer JM","Rader DJ","Marz W","Quertermous T","Doering A","Lumley T","Bis J","Kivimaki M","Linsel-Nitschke P","Heckbert S","Illig T","Guardiola M","Rupprecht HJ","van Duijn C","Kent KM","Sofat R","Fortmann S","Waterworth DM","Chen IY","Epstein SE","Knouff CW","Winkelmann BR","Thompson JR","Harris T","Bickel C","Smith A","Lackner K","Burnett MS","Folkersen L","Hingorani AD","Wichmann H-","Barbalic M","Elosua R","Ball SG","Smith N","Burtt N","Halperin E","Hakonarson HH","Wild P","Stojakovic T","Humphries SE","Kumari M"],"additional_accession":[]},"is_claimable":false,"name":"Novel genetic approach to investigate the role of plasma secretory phospholipase A2 (sPLA2)-V isoenzyme in coronary heart disease: modified Mendelian randomization analysis using PLA2G5 expression levels.","description":"<h4>Background</h4>Secretory phospholipase A2 (sPLA2) enzymes are considered to play a role in atherosclerosis. sPLA2 activity encompasses several sPLA2 isoenzymes, including sPLA2-V. Although observational studies show a strong association between elevated sPLA2 activity and CHD, no assay to measure sPLA2-V levels exists, and the only evidence linking the sPLA2-V isoform to atherosclerosis progression comes from animal studies. In the absence of an assay that directly quantifies sPLA2-V levels, we used PLA2G5 mRNA levels in a novel, modified Mendelian randomization approach to investigate the hypothesized causal role of sPLA2-V in coronary heart disease (CHD) pathogenesis.<h4>Methods and results</h4>Using data from the Advanced Study of Aortic Pathology, we identified the single-nucleotid","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Apr","modification":"2026-05-03T22:35:06.359Z","creation":"2025-07-02T03:05:37.502Z"},"accession":"S-EPMC4212409","cross_references":{"pubmed":["24563418"],"doi":["10.1161/CIRCGENETICS.113.000271","10.1161/circgenetics.113.000271"]}}