biostudies-literatureUnknown10Tonoi TThe first total synthesis of the proposed structure of astakolactin, a sesterterpene metabolite isolated from the marine sponge Cacospongia scalaris, has been achieved, mainly featuring Johnson-Claisen rearrangement, asymmetric Mukaiyama aldol reaction and MNBA-mediated lactonization.Beilstein journal of organic chemistry2421-7https://www.ebi.ac.uk/biostudies/studies/S-EPMC4222296biostudies-literatureTotal synthesis of the proposed structure of astakolactin.PMC4222296Shiina IMameda KTonoi TYoshinaga YFujishiro MfalseTotal synthesis of the proposed structure of astakolactin.The first total synthesis of the proposed structure of astakolactin, a sesterterpene metabolite isolated from the marine sponge Cacospongia scalaris, has been achieved, mainly featuring Johnson-Claisen rearrangement, asymmetric Mukaiyama aldol reaction and MNBA-mediated lactonization.2014-01-01T00:00:00Z20142025-04-18T16:18:06.074Z2019-03-27T01:38:59ZS-EPMC42222962538311210.3762/bjoc.10.252