{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Zhang F"],"pubmed_abstract":["<h4>Background</h4>Y haplogroup analyses are an important component of genealogical reconstruction, population genetic analyses, medical genetics and forensics. These fields are increasingly moving towards use of low-coverage, high throughput sequencing. While there have been methods recently proposed for assignment of Y haplogroups on the basis of high-coverage sequence data, assignment on the basis of low-coverage data remains challenging.<h4>Results</h4>We developed a new algorithm, YHap, which uses an imputation framework to jointly predict Y chromosome genotypes and assign Y haplogroups using low coverage population sequence data. We use data from the 1000 genomes project to demonstrate that YHap provides accurate Y haplogroup assignment with less than 2x coverage.<h4>Conclusions</h4>"],"journal":["BMC bioinformatics"],"pagination":["331"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4225519"],"repository":["biostudies-literature"],"pubmed_title":["YHap: a population model for probabilistic assignment of Y haplogroups from re-sequencing data."],"pmcid":["PMC4225519"],"pubmed_authors":["Li G","Zhang F","Li Y","Yu C","Coin LJ","Liu D","Yao X","Jin Y","Chen R"],"additional_accession":[]},"is_claimable":false,"name":"YHap: a population model for probabilistic assignment of Y haplogroups from re-sequencing data.","description":"<h4>Background</h4>Y haplogroup analyses are an important component of genealogical reconstruction, population genetic analyses, medical genetics and forensics. These fields are increasingly moving towards use of low-coverage, high throughput sequencing. While there have been methods recently proposed for assignment of Y haplogroups on the basis of high-coverage sequence data, assignment on the basis of low-coverage data remains challenging.<h4>Results</h4>We developed a new algorithm, YHap, which uses an imputation framework to jointly predict Y chromosome genotypes and assign Y haplogroups using low coverage population sequence data. We use data from the 1000 genomes project to demonstrate that YHap provides accurate Y haplogroup assignment with less than 2x coverage.<h4>Conclusions</h4>","dates":{"release":"2013-01-01T00:00:00Z","publication":"2013 Nov","modification":"2026-05-02T09:45:16.681Z","creation":"2026-04-07T17:53:06.252Z"},"accession":"S-EPMC4225519","cross_references":{"pubmed":["24252171"],"doi":["10.1186/1471-2105-14-331"]}}