{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Thyagarajan B"],"funding":["NIA NIH HHS","NHLBI NIH HHS"],"pagination":["134"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4228089"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15"],"pubmed_abstract":["<h4>Background</h4>Reduced forced expiratory volume in 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) are strong predictors of mortality and lung function is higher among individuals with exceptional longevity. However, genetic factors associated with lung function in individuals with exceptional longevity have not been identified.<h4>Method</h4>We conducted a genome wide association study (GWAS) to identify novel genetic variants associated with lung function in the Long Life Family Study (LLFS) (n = 3,899). Replication was performed using data from the CHARGE/SpiroMeta consortia. The association between SNPs and FEV1 and FEV1/FVC was analyzed using a linear mixed effects model adjusted for age, age2, sex, height, field center, ancestry principal components and kinsh"],"journal":["Respiratory research"],"pubmed_title":["Genetic variants associated with lung function: the long life family study."],"pmcid":["PMC4228089"],"funding_grant_id":["P30 AG034424","RC1 HL100543","R01 HL077612","U01 AG023744","U01 AG023712","U01 AG023749","P30 AG024827","U01 AG023746"],"pubmed_authors":["Thyagarajan B","Sanders J","Newman A","Wojczynski M","Minster RL","Barr RG","Barral S","CHARGE consortium, SpiroMeta consortium","Christiansen L"],"additional_accession":[]},"is_claimable":false,"name":"Genetic variants associated with lung function: the long life family study.","description":"<h4>Background</h4>Reduced forced expiratory volume in 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (FVC) are strong predictors of mortality and lung function is higher among individuals with exceptional longevity. However, genetic factors associated with lung function in individuals with exceptional longevity have not been identified.<h4>Method</h4>We conducted a genome wide association study (GWAS) to identify novel genetic variants associated with lung function in the Long Life Family Study (LLFS) (n = 3,899). Replication was performed using data from the CHARGE/SpiroMeta consortia. The association between SNPs and FEV1 and FEV1/FVC was analyzed using a linear mixed effects model adjusted for age, age2, sex, height, field center, ancestry principal components and kinsh","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Nov","modification":"2026-06-10T05:43:19.733Z","creation":"2026-06-10T03:07:48.322Z"},"accession":"S-EPMC4228089","cross_references":{"pubmed":["25409777"],"doi":["10.1186/s12931-014-0134-x"]}}