{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhou J"],"funding":["American Heart Association","Natural Science Foundation of China","NHLBI NIH HHS","Priority Academic Program Development of Jiangsu Higher Education Institutions","Temple University School of Medicine","NIH"],"pagination":["1890-7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4229395"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(11)"],"pubmed_abstract":["<h4>Background</h4>ERp57 is required for platelet function; however, whether ERp57 contributes to fibrin generation is unknown.<h4>Methods and results</h4>Using an inhibitory anti-ERp57 antibody (mAb1), Pf4-Cre/ERp57(fl/fl) mice, Tie2-Cre/ERp57(fl/fl) mice, and mutants of ERp57, we analyzed the function of ERp57 in laser-induced thrombosis. Fibrin deposition was decreased in Pf4-Cre/ERp57(fl/fl) mice, consistent with a role for platelet ERp57 in fibrin generation. Fibrin deposition was further decreased with infusion of mAb1 and in Tie2-Cre/ERp57(fl/fl) mice, consistent with endothelial cells also contributing to fibrin deposition. Infusion of eptibifatide inhibited platelet and fibrin deposition, confirming a role for platelets in fibrin deposition. Infusion of recombinant ERp57 corrected"],"journal":["Journal of thrombosis and haemostasis : JTH"],"pubmed_title":["The disulfide isomerase ERp57 is required for fibrin deposition in vivo."],"pmcid":["PMC4229395"],"funding_grant_id":["P01 HL110860","P01 HL064190","31201058","U01 HL099656","1R01HL118526","U01 HL099993","81270592","R01 HL118526"],"pubmed_authors":["Hayes VM","Rauova L","Poncz M","Essex DW","Wu Y","Zhou J","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"The disulfide isomerase ERp57 is required for fibrin deposition in vivo.","description":"<h4>Background</h4>ERp57 is required for platelet function; however, whether ERp57 contributes to fibrin generation is unknown.<h4>Methods and results</h4>Using an inhibitory anti-ERp57 antibody (mAb1), Pf4-Cre/ERp57(fl/fl) mice, Tie2-Cre/ERp57(fl/fl) mice, and mutants of ERp57, we analyzed the function of ERp57 in laser-induced thrombosis. Fibrin deposition was decreased in Pf4-Cre/ERp57(fl/fl) mice, consistent with a role for platelet ERp57 in fibrin generation. Fibrin deposition was further decreased with infusion of mAb1 and in Tie2-Cre/ERp57(fl/fl) mice, consistent with endothelial cells also contributing to fibrin deposition. Infusion of eptibifatide inhibited platelet and fibrin deposition, confirming a role for platelets in fibrin deposition. Infusion of recombinant ERp57 corrected","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Nov","modification":"2025-07-02T03:04:29.758Z","creation":"2025-07-02T03:04:29.758Z"},"accession":"S-EPMC4229395","cross_references":{"pubmed":["25156521"],"doi":["10.1111/jth.12709"]}}