{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Iulita MF"],"funding":["Canadian Institutes of Health Research"],"pagination":["61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4229908"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2"],"pubmed_abstract":["Numerous studies have implicated the abnormal accumulation of intraneuronal amyloid-β (Aβ) as an important contributor to Alzheimer's disease (AD) pathology, capable of triggering neuroinflammation, tau hyperphosphorylation and cognitive deficits. However, the occurrence and pathological relevance of intracellular Aβ remain a matter of controversial debate. In this study, we have used a multidimensional approach including high-magnification and super-resolution microscopy, cerebro-spinal fluid (CSF) mass spectrometry analysis and ELISA to investigate the Aβ pathology and its associated cognitive impairments, in a novel transgenic rat model overexpressing human APP. Our microscopy studies with quantitative co-localization analysis revealed the presence of intraneuronal Aβ in transgenic rats"],"journal":["Acta neuropathologica communications"],"pubmed_title":["Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study."],"pmcid":["PMC4229908"],"funding_grant_id":["MOP-97776"],"pubmed_authors":["Klein WL","Allard S","Do Carmo S","Munter LM","Weise C","Iulita MF","Richter L","Multhaup G","Cuello AC","Ducatenzeiler A"],"additional_accession":[]},"is_claimable":false,"name":"Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study.","description":"Numerous studies have implicated the abnormal accumulation of intraneuronal amyloid-β (Aβ) as an important contributor to Alzheimer's disease (AD) pathology, capable of triggering neuroinflammation, tau hyperphosphorylation and cognitive deficits. However, the occurrence and pathological relevance of intracellular Aβ remain a matter of controversial debate. In this study, we have used a multidimensional approach including high-magnification and super-resolution microscopy, cerebro-spinal fluid (CSF) mass spectrometry analysis and ELISA to investigate the Aβ pathology and its associated cognitive impairments, in a novel transgenic rat model overexpressing human APP. Our microscopy studies with quantitative co-localization analysis revealed the presence of intraneuronal Aβ in transgenic rats","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Jun","modification":"2025-04-05T00:20:30.91Z","creation":"2019-03-27T01:39:33Z"},"accession":"S-EPMC4229908","cross_references":{"pubmed":["24903713"],"doi":["10.1186/2051-5960-2-61"]}}