{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(11)"],"submitter":["Carrieri PM"],"pubmed_abstract":["Objective
Methadone coverage is poor in many countries due in part to methadone induction being possible only in specialized care (SC). This multicenter pragmatic trial compared the effectiveness of methadone treatment between two induction models: primary care (PC) and SC.Methods
In this study, registered at ClinicalTrials.Gov (NCT00657397), opioid-dependent individuals not on methadone treatment for at least one month or receiving buprenorphine but needing to switch were randomly assigned to start methadone in PC (N = 155) or in SC (N = 66) in 10 sites in France. Visits were scheduled at months M0, M3, M6 and M12. The primary outcome was self-reported abstinence from street-opioids at 12 months (M12) (with an underlying 15% non-inferiority hypothesis for PC). Secondary ou"],"journal":["PloS one"],"pagination":["e112328"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4231094"],"repository":["biostudies-literature"],"pubmed_title":["Methadone induction in primary care for opioid dependence: a pragmatic randomized trial (ANRS Methaville)."],"pmcid":["PMC4231094"],"pubmed_authors":["Lavignasse","Lasalarie","Methaville Study Group","Bry","Dewost","Herouin","Guena","Truffy","Metz","Aubertin","Marre","Achard","Roch","Bibette","Cadart","Herran","Paillou","Gutekunst","Roux P","Raulin","Guillet","Michel L","Biderman","Balteau Bijeau","Carrieri PM","Marcellin F","Le Havre","Partouche","Kerloc","Lions C","Michel","Mauraycaplanne","Daulouede","Gassmann","Nemayechi","Rouille","Spire B","Vincent","Morel A","Mora M","Magnin","Bartolo","Khouri","Vray M","Pouclet","Cohen J","Vergez","Petit","Jacob"],"additional_accession":[]},"is_claimable":false,"name":"Methadone induction in primary care for opioid dependence: a pragmatic randomized trial (ANRS Methaville).","description":"Objective
Methadone coverage is poor in many countries due in part to methadone induction being possible only in specialized care (SC). This multicenter pragmatic trial compared the effectiveness of methadone treatment between two induction models: primary care (PC) and SC.Methods
In this study, registered at ClinicalTrials.Gov (NCT00657397), opioid-dependent individuals not on methadone treatment for at least one month or receiving buprenorphine but needing to switch were randomly assigned to start methadone in PC (N = 155) or in SC (N = 66) in 10 sites in France. Visits were scheduled at months M0, M3, M6 and M12. The primary outcome was self-reported abstinence from street-opioids at 12 months (M12) (with an underlying 15% non-inferiority hypothesis for PC). Secondary ou","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2026-05-04T00:31:37.56Z","creation":"2026-04-07T19:52:06.73Z"},"accession":"S-EPMC4231094","cross_references":{"pubmed":["25393311"],"doi":["10.1371/journal.pone.0112328"]}}