biostudies-literatureUnknown15Qu J<h4>Background</h4>Chronic hepatitis B (CHB) can progress to cirrhosis, hepatocellular carcinoma (HCC) and ultimately liver-related death. Although oral antiviral therapy for patients with CHB reduces the risk of such complications, once cirrhosis is established, the benefits of antiviral therapy are not robustly demonstrated. According to traditional Chinese medicine (TCM), some Chinese herbal medicines promote blood circulation and soften hard masses, and therefore they may block and reverse hepatic fibrosis. The aim of this study is to evaluate the effects of TCM tablets of the compound biejia ruangan (RGT) administered for fibrosis, and entecavir (ETV), on the development of HCC in patients with CHB or hepatitis B virus (HBV)-related compensated cirrhosis.<h4>Methods/design</h4>This muTrials438https://www.ebi.ac.uk/biostudies/studies/S-EPMC4234899biostudies-literatureBlocking and reversing hepatic fibrosis in patients with chronic hepatitis B treated by traditional Chinese medicine (tablets of biejia ruangan or RGT): study protocol for a randomized controlled trial.PMC4234899Rong GLu WWang CLu YHu XDong ZQu JLei CShang QXiang DQi XChen YWang XYu ZZhang CTan LLi HZhou LChen JChen LChen GZeng ZLi QBai WChen DLi YLi ZYang YXiao GLou MfalseBlocking and reversing hepatic fibrosis in patients with chronic hepatitis B treated by traditional Chinese medicine (tablets of biejia ruangan or RGT): study protocol for a randomized controlled trial.<h4>Background</h4>Chronic hepatitis B (CHB) can progress to cirrhosis, hepatocellular carcinoma (HCC) and ultimately liver-related death. Although oral antiviral therapy for patients with CHB reduces the risk of such complications, once cirrhosis is established, the benefits of antiviral therapy are not robustly demonstrated. According to traditional Chinese medicine (TCM), some Chinese herbal medicines promote blood circulation and soften hard masses, and therefore they may block and reverse hepatic fibrosis. The aim of this study is to evaluate the effects of TCM tablets of the compound biejia ruangan (RGT) administered for fibrosis, and entecavir (ETV), on the development of HCC in patients with CHB or hepatitis B virus (HBV)-related compensated cirrhosis.<h4>Methods/design</h4>This mu2014-01-01T00:00:00Z2014 Nov2025-04-04T20:49:12.524Z2019-03-27T01:39:47ZS-EPMC42348992538172110.1186/1745-6215-15-438