{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mak RH"],"funding":["NCI NIH HHS"],"pagination":["3801-9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4239302"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(34)"],"pubmed_abstract":["Purpose
Multiple prospective Radiation Therapy Oncology Group (RTOG) protocols have evaluated bladder-preserving combined-modality therapy (CMT) for muscle-invasive bladder cancer (MIBC), reserving cystectomy for salvage treatment. We performed a pooled analysis of long-term outcomes in patients with MIBC enrolled across multiple studies.Patients and methods
Four hundred sixty-eight patients with MIBC were enrolled onto six RTOG bladder-preservation studies, including five phase II studies (RTOG 8802, 9506, 9706, 9906, and 0233) and one phase III study (RTOG 8903). Overall survival (OS) was estimated using the Kaplan-Meier method, and disease-specific survival (DSS), muscle-invasive and non-muscle-invasive local failure (LF), and distant metastasis (DM) were estimated by th"],"journal":["Journal of clinical oncology : official journal of the American Society of Clinical Oncology"],"pubmed_title":["Long-term outcomes in patients with muscle-invasive bladder cancer after selective bladder-preserving combined-modality therapy: a pooled analysis of Radiation Therapy Oncology Group protocols 8802, 8903, 9506, 9706, 9906, and 0233."],"pmcid":["PMC4239302"],"funding_grant_id":["U10 CA037422","UG1 CA189867","U10 CA21661","U10 CA021661","U10 CA180868","U10 CA180822","U10 CA37422"],"pubmed_authors":["Mak RH","Efstathiou JA","Hagan MP","Hunt D","Tester WJ","Zietman AL","Kaufman DS","Shipley WU","Heney NM"],"additional_accession":[]},"is_claimable":false,"name":"Long-term outcomes in patients with muscle-invasive bladder cancer after selective bladder-preserving combined-modality therapy: a pooled analysis of Radiation Therapy Oncology Group protocols 8802, 8903, 9506, 9706, 9906, and 0233.","description":"Purpose
Multiple prospective Radiation Therapy Oncology Group (RTOG) protocols have evaluated bladder-preserving combined-modality therapy (CMT) for muscle-invasive bladder cancer (MIBC), reserving cystectomy for salvage treatment. We performed a pooled analysis of long-term outcomes in patients with MIBC enrolled across multiple studies.Patients and methods
Four hundred sixty-eight patients with MIBC were enrolled onto six RTOG bladder-preservation studies, including five phase II studies (RTOG 8802, 9506, 9706, 9906, and 0233) and one phase III study (RTOG 8903). Overall survival (OS) was estimated using the Kaplan-Meier method, and disease-specific survival (DSS), muscle-invasive and non-muscle-invasive local failure (LF), and distant metastasis (DM) were estimated by th","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Dec","modification":"2026-04-18T07:32:30.704Z","creation":"2019-03-27T01:40:00Z"},"accession":"S-EPMC4239302","cross_references":{"pubmed":["25366678"],"doi":["10.1200/jco.2014.57.5548","10.1200/JCO.2014.57.5548"]}}