biostudies-literatureMak RHNCI NIH HHS3801-9https://www.ebi.ac.uk/biostudies/studies/S-EPMC4239302biostudies-literatureUnknown32(34)<h4>Purpose</h4>Multiple prospective Radiation Therapy Oncology Group (RTOG) protocols have evaluated bladder-preserving combined-modality therapy (CMT) for muscle-invasive bladder cancer (MIBC), reserving cystectomy for salvage treatment. We performed a pooled analysis of long-term outcomes in patients with MIBC enrolled across multiple studies.<h4>Patients and methods</h4>Four hundred sixty-eight patients with MIBC were enrolled onto six RTOG bladder-preservation studies, including five phase II studies (RTOG 8802, 9506, 9706, 9906, and 0233) and one phase III study (RTOG 8903). Overall survival (OS) was estimated using the Kaplan-Meier method, and disease-specific survival (DSS), muscle-invasive and non-muscle-invasive local failure (LF), and distant metastasis (DM) were estimated by thJournal of clinical oncology : official journal of the American Society of Clinical OncologyLong-term outcomes in patients with muscle-invasive bladder cancer after selective bladder-preserving combined-modality therapy: a pooled analysis of Radiation Therapy Oncology Group protocols 8802, 8903, 9506, 9706, 9906, and 0233.PMC4239302U10 CA037422UG1 CA189867U10 CA21661U10 CA021661U10 CA180868U10 CA180822U10 CA37422Mak RHEfstathiou JAHagan MPHunt DTester WJZietman ALKaufman DSShipley WUHeney NMfalseLong-term outcomes in patients with muscle-invasive bladder cancer after selective bladder-preserving combined-modality therapy: a pooled analysis of Radiation Therapy Oncology Group protocols 8802, 8903, 9506, 9706, 9906, and 0233.<h4>Purpose</h4>Multiple prospective Radiation Therapy Oncology Group (RTOG) protocols have evaluated bladder-preserving combined-modality therapy (CMT) for muscle-invasive bladder cancer (MIBC), reserving cystectomy for salvage treatment. We performed a pooled analysis of long-term outcomes in patients with MIBC enrolled across multiple studies.<h4>Patients and methods</h4>Four hundred sixty-eight patients with MIBC were enrolled onto six RTOG bladder-preservation studies, including five phase II studies (RTOG 8802, 9506, 9706, 9906, and 0233) and one phase III study (RTOG 8903). Overall survival (OS) was estimated using the Kaplan-Meier method, and disease-specific survival (DSS), muscle-invasive and non-muscle-invasive local failure (LF), and distant metastasis (DM) were estimated by th2014-01-01T00:00:00Z2014 Dec2026-04-18T07:32:30.704Z2019-03-27T01:40:00ZS-EPMC42393022536667810.1200/jco.2014.57.554810.1200/JCO.2014.57.5548