{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["35(11)"],"submitter":["Chen J"],"pubmed_abstract":["The aims of this work are to study the antitumor effect of the adeno-associated virus on the xenografted tumors of chick embryo chorioallantoic membrane and predict potential genes and biological pathways which are associated with renal cell carcinoma. The adeno-associated virus NT4-TAT-6 × His-VHLbeta was constructed and identified. Then, chick embryos with xenografted tumor were divided into three groups and respectively inoculated with rAAV/NT4-TAT-6 × His-VHLbeta (group A), empty virus (group B), and phosphate-buffered saline (group C, the control subject). Antitumor effect in each group was investigated by means of immunofluorescence observation. Genes interacted with von Hippel-Lindau were screened by Search Tool for the Retrieval of Interacting Genes/Proteins database, while pathway"],"journal":["Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine"],"pagination":["10993-1003"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4244535"],"repository":["biostudies-literature"],"pubmed_title":["Antitumor effect and biological pathways of a recombinant adeno-associated virus as a human renal cell carcinoma suppressor."],"pmcid":["PMC4244535"],"pubmed_authors":["Ruan X","Chen J","Wang S","Liu Q","Liu B","Zhang B","Sun Z"],"additional_accession":[]},"is_claimable":false,"name":"Antitumor effect and biological pathways of a recombinant adeno-associated virus as a human renal cell carcinoma suppressor.","description":"The aims of this work are to study the antitumor effect of the adeno-associated virus on the xenografted tumors of chick embryo chorioallantoic membrane and predict potential genes and biological pathways which are associated with renal cell carcinoma. The adeno-associated virus NT4-TAT-6 × His-VHLbeta was constructed and identified. Then, chick embryos with xenografted tumor were divided into three groups and respectively inoculated with rAAV/NT4-TAT-6 × His-VHLbeta (group A), empty virus (group B), and phosphate-buffered saline (group C, the control subject). Antitumor effect in each group was investigated by means of immunofluorescence observation. Genes interacted with von Hippel-Lindau were screened by Search Tool for the Retrieval of Interacting Genes/Proteins database, while pathway","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Nov","modification":"2025-05-29T20:07:36.461Z","creation":"2025-05-29T20:07:36.461Z"},"accession":"S-EPMC4244535","cross_references":{"pubmed":["25091575"],"doi":["10.1007/s13277-014-2393-z"]}}