biostudies-literatureUnknown35(11)Chen JThe aims of this work are to study the antitumor effect of the adeno-associated virus on the xenografted tumors of chick embryo chorioallantoic membrane and predict potential genes and biological pathways which are associated with renal cell carcinoma. The adeno-associated virus NT4-TAT-6 × His-VHLbeta was constructed and identified. Then, chick embryos with xenografted tumor were divided into three groups and respectively inoculated with rAAV/NT4-TAT-6 × His-VHLbeta (group A), empty virus (group B), and phosphate-buffered saline (group C, the control subject). Antitumor effect in each group was investigated by means of immunofluorescence observation. Genes interacted with von Hippel-Lindau were screened by Search Tool for the Retrieval of Interacting Genes/Proteins database, while pathwayTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine10993-1003https://www.ebi.ac.uk/biostudies/studies/S-EPMC4244535biostudies-literatureAntitumor effect and biological pathways of a recombinant adeno-associated virus as a human renal cell carcinoma suppressor.PMC4244535Ruan XChen JWang SLiu QLiu BZhang BSun ZfalseAntitumor effect and biological pathways of a recombinant adeno-associated virus as a human renal cell carcinoma suppressor.The aims of this work are to study the antitumor effect of the adeno-associated virus on the xenografted tumors of chick embryo chorioallantoic membrane and predict potential genes and biological pathways which are associated with renal cell carcinoma. The adeno-associated virus NT4-TAT-6 × His-VHLbeta was constructed and identified. Then, chick embryos with xenografted tumor were divided into three groups and respectively inoculated with rAAV/NT4-TAT-6 × His-VHLbeta (group A), empty virus (group B), and phosphate-buffered saline (group C, the control subject). Antitumor effect in each group was investigated by means of immunofluorescence observation. Genes interacted with von Hippel-Lindau were screened by Search Tool for the Retrieval of Interacting Genes/Proteins database, while pathway2014-01-01T00:00:00Z2014 Nov2025-05-29T20:07:36.461Z2025-05-29T20:07:36.461ZS-EPMC42445352509157510.1007/s13277-014-2393-z