biostudies-literatureUnknown4(11)Jin YJ<h4>Objective</h4>To evaluate clinicobiochemical factors predicting severe hepatic fibrosis in patients with chronic hepatitis C virus (HCV) infection.<h4>Setting</h4>Tertiary institution.<h4>Participants</h4>859 treatment-naïve Korean patients with HCV who underwent liver biopsy. Severe fibrosis was defined as fibrosis stage ≥3 based on the METAVIR system.<h4>Primary outcome measures</h4>Clinicobiochemical factors predicting severe hepatic fibrosis.<h4>Results</h4>The median serum alanine aminotransferase (ALT) level was 68 IU/L and body mass index (BMI) was 24.2 kg/m(2). Severe fibrosis was observed in 326 (39.7%) of the 859 patients. The frequencies of severe fibrosis were 0%, 37.8%, 41.9% and 42% in patients with serum ALT concentrations (IU/L) of ≤20, 20-30, 30-40 and >40 (p<0.01), reBMJ opene006255https://www.ebi.ac.uk/biostudies/studies/S-EPMC4248083biostudies-literatureClinicobiochemical prediction of biopsy-proven cases of severe hepatic fibrosis in patients with chronic hepatitis C infection.PMC4248083Lim YSJin YJLee HCShim JHKim KMYu EKim GAfalseClinicobiochemical prediction of biopsy-proven cases of severe hepatic fibrosis in patients with chronic hepatitis C infection.<h4>Objective</h4>To evaluate clinicobiochemical factors predicting severe hepatic fibrosis in patients with chronic hepatitis C virus (HCV) infection.<h4>Setting</h4>Tertiary institution.<h4>Participants</h4>859 treatment-naïve Korean patients with HCV who underwent liver biopsy. Severe fibrosis was defined as fibrosis stage ≥3 based on the METAVIR system.<h4>Primary outcome measures</h4>Clinicobiochemical factors predicting severe hepatic fibrosis.<h4>Results</h4>The median serum alanine aminotransferase (ALT) level was 68 IU/L and body mass index (BMI) was 24.2 kg/m(2). Severe fibrosis was observed in 326 (39.7%) of the 859 patients. The frequencies of severe fibrosis were 0%, 37.8%, 41.9% and 42% in patients with serum ALT concentrations (IU/L) of ≤20, 20-30, 30-40 and >40 (p<0.01), re2014-01-01T00:00:00Z2014 Nov2025-04-19T23:10:55.137Z2019-03-27T01:40:30ZS-EPMC42480832543122310.1136/bmjopen-2014-006255