{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(44)"],"submitter":["Yoon YS"],"pubmed_abstract":["The evaluation of therapeutic efficacy is necessary to predict the outcome of patients with metastatic colorectal cancer (CRC). In these patients, there is a critical need for predictive chemosensitivity assays and biomarkers to optimize efficacy and minimize toxicity. The introduction of targeted agents has improved the progression-free survival and overall survival of patients with metastatic disease. However, approximately 50% of patients do not show a positive response to chemotherapy and the selection of patients likely to respond to a specific regimen remains challenging. Cell culture-based chemosensitivity tests use autologous viable tumor cells to evaluate susceptibility to specific agents in vitro and predict their direct effects. Adenosine triphosphate-based assays and methyl thi"],"journal":["World journal of gastroenterology"],"pagination":["16398-408"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4248183"],"repository":["biostudies-literature"],"pubmed_title":["Recent applications of chemosensitivity tests for colorectal cancer treatment."],"pmcid":["PMC4248183"],"pubmed_authors":["Yoon YS","Kim JC"],"additional_accession":[]},"is_claimable":false,"name":"Recent applications of chemosensitivity tests for colorectal cancer treatment.","description":"The evaluation of therapeutic efficacy is necessary to predict the outcome of patients with metastatic colorectal cancer (CRC). In these patients, there is a critical need for predictive chemosensitivity assays and biomarkers to optimize efficacy and minimize toxicity. The introduction of targeted agents has improved the progression-free survival and overall survival of patients with metastatic disease. However, approximately 50% of patients do not show a positive response to chemotherapy and the selection of patients likely to respond to a specific regimen remains challenging. Cell culture-based chemosensitivity tests use autologous viable tumor cells to evaluate susceptibility to specific agents in vitro and predict their direct effects. Adenosine triphosphate-based assays and methyl thi","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Nov","modification":"2025-05-31T23:43:33.212Z","creation":"2019-03-27T01:40:30Z"},"accession":"S-EPMC4248183","cross_references":{"pubmed":["25469008"],"doi":["10.3748/wjg.v20.i44.16398"]}}