{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["4(1-2)"],"submitter":["Sidhu J"],"pubmed_abstract":["<h4>Introduction</h4>Standard treatment for patients with primary immunodeficiency (PID) is monthly intravenous immunoglobulin (IVIG), or weekly/biweekly subcutaneous immunoglobulin (SCIG) infusion. We used population pharmacokinetic modeling to predict immunoglobulin G (IgG) exposure following a broad range of SCIG dosing regimens for initiation and maintenance therapy in patients with PID.<h4>Methods</h4>Simulations of SCIG dosing were performed to predict IgG concentration-time profiles and exposure metrics [steady-state area under the IgG concentration-time curve (AUC), IgG peak concentration (C max), and IgG trough concentration (C min) ratios] for various infusion regimens.<h4>Results</h4>The equivalent of a weekly SCIG maintenance dose administered one, two, three, five, or seven ti"],"journal":["Biologics in therapy"],"pagination":["41-55"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4254869"],"repository":["biostudies-literature"],"pubmed_title":["Enhancing Patient Flexibility of Subcutaneous Immunoglobulin G Dosing: Pharmacokinetic Outcomes of Various Maintenance and Loading Regimens in the Treatment of Primary Immunodeficiency."],"pmcid":["PMC4254869"],"pubmed_authors":["Sidhu J","Pfister M","Edelman J","Rojavin M"],"additional_accession":[]},"is_claimable":false,"name":"Enhancing Patient Flexibility of Subcutaneous Immunoglobulin G Dosing: Pharmacokinetic Outcomes of Various Maintenance and Loading Regimens in the Treatment of Primary Immunodeficiency.","description":"<h4>Introduction</h4>Standard treatment for patients with primary immunodeficiency (PID) is monthly intravenous immunoglobulin (IVIG), or weekly/biweekly subcutaneous immunoglobulin (SCIG) infusion. We used population pharmacokinetic modeling to predict immunoglobulin G (IgG) exposure following a broad range of SCIG dosing regimens for initiation and maintenance therapy in patients with PID.<h4>Methods</h4>Simulations of SCIG dosing were performed to predict IgG concentration-time profiles and exposure metrics [steady-state area under the IgG concentration-time curve (AUC), IgG peak concentration (C max), and IgG trough concentration (C min) ratios] for various infusion regimens.<h4>Results</h4>The equivalent of a weekly SCIG maintenance dose administered one, two, three, five, or seven ti","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Dec","modification":"2026-05-03T02:25:51.315Z","creation":"2019-03-27T01:40:53Z"},"accession":"S-EPMC4254869","cross_references":{"pubmed":["25118975"],"doi":["10.1007/s13554-014-0018-0"]}}