{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(12)"],"submitter":["Chakraborty M"],"pubmed_abstract":["<h4>Rationale</h4>The chemokine interleukin-8 is implicated in the development of bronchopulmonary dysplasia in preterm infants. The 77-amino acid isoform of interleukin-8 (interleukin-877) is a less potent chemoattractant than other shorter isoforms. Although interleukin-877 is abundant in the preterm circulation, its regulation in the preterm lung is unknown.<h4>Objectives</h4>To study expression and processing of pulmonary interleukin-877 in preterm infants who did and did not develop bronchopulmonary dysplasia.<h4>Methods</h4>Total interleukin-8 and interleukin-877 were measured in bronchoalveolar lavage fluid from preterm infants by immunoassay. Neutrophil serine proteases were used to assess processing. Neutrophil chemotaxis assays and degranulation of neutrophil matrix metalloprotei"],"journal":["PloS one"],"pagination":["e114524"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4256433"],"repository":["biostudies-literature"],"pubmed_title":["Role of serine proteases in the regulation of interleukin-877 during the development of bronchopulmonary dysplasia in preterm ventilated infants."],"pmcid":["PMC4256433"],"pubmed_authors":["Powell W","Davies PL","Hogwood J","Gray E","McGreal EP","Spiller B","Kotecha S","Voitenok NN","Chambers RC","Williams A","Chakraborty M","Abdulla S"],"additional_accession":[]},"is_claimable":false,"name":"Role of serine proteases in the regulation of interleukin-877 during the development of bronchopulmonary dysplasia in preterm ventilated infants.","description":"<h4>Rationale</h4>The chemokine interleukin-8 is implicated in the development of bronchopulmonary dysplasia in preterm infants. The 77-amino acid isoform of interleukin-8 (interleukin-877) is a less potent chemoattractant than other shorter isoforms. Although interleukin-877 is abundant in the preterm circulation, its regulation in the preterm lung is unknown.<h4>Objectives</h4>To study expression and processing of pulmonary interleukin-877 in preterm infants who did and did not develop bronchopulmonary dysplasia.<h4>Methods</h4>Total interleukin-8 and interleukin-877 were measured in bronchoalveolar lavage fluid from preterm infants by immunoassay. Neutrophil serine proteases were used to assess processing. Neutrophil chemotaxis assays and degranulation of neutrophil matrix metalloprotei","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2026-07-16T07:27:20.399Z","creation":"2019-03-26T23:25:08Z"},"accession":"S-EPMC4256433","cross_references":{"pubmed":["25474412"],"doi":["10.1371/journal.pone.0114524"]}}