{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Althubiti M"],"funding":["Cancer Research UK","Medical Research Council"],"pagination":["e1528"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4260747"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5"],"pubmed_abstract":["Cellular senescence is a terminal differentiation state that has been proposed to have a role in both tumour suppression and ageing. This view is supported by the fact that accumulation of senescent cells can be observed in response to oncogenic stress as well as a result of normal organismal ageing. Thus, identifying senescent cells in in vivo and in vitro has an important diagnostic and therapeutic potential. The molecular pathways involved in triggering and/or maintaining the senescent phenotype are not fully understood. As a consequence, the markers currently utilized to detect senescent cells are limited and lack specificity. In order to address this issue, we screened for plasma membrane-associated proteins that are preferentially expressed in senescent cells. We identified 107 prote"],"journal":["Cell death & disease"],"pubmed_title":["Characterization of novel markers of senescence and their prognostic potential in cancer."],"pmcid":["PMC4260747"],"funding_grant_id":["13083","18370"],"pubmed_authors":["Jukes-Jones R","Cain K","Macip S","Althubiti M","Giblett SM","Saldanha GS","Carrera S","Barlev N","Lezina L","Antonov A","Pritchard CA"],"additional_accession":[]},"is_claimable":false,"name":"Characterization of novel markers of senescence and their prognostic potential in cancer.","description":"Cellular senescence is a terminal differentiation state that has been proposed to have a role in both tumour suppression and ageing. This view is supported by the fact that accumulation of senescent cells can be observed in response to oncogenic stress as well as a result of normal organismal ageing. Thus, identifying senescent cells in in vivo and in vitro has an important diagnostic and therapeutic potential. The molecular pathways involved in triggering and/or maintaining the senescent phenotype are not fully understood. As a consequence, the markers currently utilized to detect senescent cells are limited and lack specificity. In order to address this issue, we screened for plasma membrane-associated proteins that are preferentially expressed in senescent cells. We identified 107 prote","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Nov","modification":"2026-05-03T21:25:30.099Z","creation":"2025-05-31T23:01:46.652Z"},"accession":"S-EPMC4260747","cross_references":{"pubmed":["25412306"],"doi":["10.1038/cddis.2014.489"]}}