biostudies-literatureAlthubiti MCancer Research UKMedical Research Councile1528https://www.ebi.ac.uk/biostudies/studies/S-EPMC4260747biostudies-literatureUnknown5Cellular senescence is a terminal differentiation state that has been proposed to have a role in both tumour suppression and ageing. This view is supported by the fact that accumulation of senescent cells can be observed in response to oncogenic stress as well as a result of normal organismal ageing. Thus, identifying senescent cells in in vivo and in vitro has an important diagnostic and therapeutic potential. The molecular pathways involved in triggering and/or maintaining the senescent phenotype are not fully understood. As a consequence, the markers currently utilized to detect senescent cells are limited and lack specificity. In order to address this issue, we screened for plasma membrane-associated proteins that are preferentially expressed in senescent cells. We identified 107 proteCell death & diseaseCharacterization of novel markers of senescence and their prognostic potential in cancer.PMC42607471308318370Jukes-Jones RCain KMacip SAlthubiti MGiblett SMSaldanha GSCarrera SBarlev NLezina LAntonov APritchard CAfalseCharacterization of novel markers of senescence and their prognostic potential in cancer.Cellular senescence is a terminal differentiation state that has been proposed to have a role in both tumour suppression and ageing. This view is supported by the fact that accumulation of senescent cells can be observed in response to oncogenic stress as well as a result of normal organismal ageing. Thus, identifying senescent cells in in vivo and in vitro has an important diagnostic and therapeutic potential. The molecular pathways involved in triggering and/or maintaining the senescent phenotype are not fully understood. As a consequence, the markers currently utilized to detect senescent cells are limited and lack specificity. In order to address this issue, we screened for plasma membrane-associated proteins that are preferentially expressed in senescent cells. We identified 107 prote2014-01-01T00:00:00Z2014 Nov2026-05-03T21:25:30.099Z2025-05-31T23:01:46.652ZS-EPMC42607472541230610.1038/cddis.2014.489