biostudies-literatureCooper TKNICHD NIH HHSNCRR NIH HHSNIEHS NIH HHSNIH HHSPHS HHS388-92https://www.ebi.ac.uk/biostudies/studies/S-EPMC4261063biostudies-literatureUnknown52(2)Chordomas are uncommon neoplasms arising from notochord remnants, most commonly occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and primary alimentary tract chordomas have not been reported. Herein we report 24 cases of spontaneous primary intestinal chordomas in zebrafish, as well as 9 spontaneous vertebral chordomas. Both intestinal and vertebral tumors showed invasive behavior, although more commonly in the latter. In all cases of primary intestinal chordomas, there was no axial or peripheral skeletal or other nonvisceral involvement. Although uncommon, intestinal chordomas represent a unique background lesion in aged zebrafish.Veterinary pathologyPrimary intestinal and vertebral chordomas in laboratory zebrafish (Danio rerio).PMC4261063P30 ES003850P30 ES0002103P40RR12546P40 RR012546R21 ES013124P40 OD011021R01ES011587P30ES00210R01 ES011587R01 HD0693213P40RR12546-03S1P30ESO3850R21ES013124Cooper TKSpagnoli SSpitsbergen JMMurray KNfalsePrimary intestinal and vertebral chordomas in laboratory zebrafish (Danio rerio).Chordomas are uncommon neoplasms arising from notochord remnants, most commonly occurring in the axial skeleton. Extraskeletal soft tissue chordomas are rare primary tumors, and primary alimentary tract chordomas have not been reported. Herein we report 24 cases of spontaneous primary intestinal chordomas in zebrafish, as well as 9 spontaneous vertebral chordomas. Both intestinal and vertebral tumors showed invasive behavior, although more commonly in the latter. In all cases of primary intestinal chordomas, there was no axial or peripheral skeletal or other nonvisceral involvement. Although uncommon, intestinal chordomas represent a unique background lesion in aged zebrafish.2015-01-01T00:00:00Z2015 Mar2024-11-19T23:05:58.601Z2019-03-27T01:41:23ZS-EPMC42610632491326910.1177/0300985814537531