biostudies-literatureUnknown11Tabynov K<h4>Background</h4>Highly pathogenic avian influenza (HPAI) H5N1 viruses continue to circulate in poultry and can infect and cause mortality in birds and mammals; the genetic determinants of their increased virulence are largely unknown. The main purpose of this work was to determine the correlation between known molecular determinants of virulence in different avian influenza virus (AIV) genes and the results of experimental infection of birds and mammals with AIV strain A/swan/Mangistau/3/06 (H5N1; SW/3/06).<h4>Methods and results</h4>We examined the virulence of SW/3/06 in four species of birds (chickens, ducks, turkeys, geese) and five species of mammals (mice, guinea pigs, cats, dogs, pigs), and identified the molecular determinants of virulence in 11 genes (HA, NA, PB1, PB1-F2, PB2, Virology journal207https://www.ebi.ac.uk/biostudies/studies/S-EPMC4264262biostudies-literatureThe pathogenicity of swan derived H5N1 virus in birds and mammals and its gene analysis.PMC4264262Tabynov KSansyzbay ASandybayev NMambetaliyev MfalseThe pathogenicity of swan derived H5N1 virus in birds and mammals and its gene analysis.<h4>Background</h4>Highly pathogenic avian influenza (HPAI) H5N1 viruses continue to circulate in poultry and can infect and cause mortality in birds and mammals; the genetic determinants of their increased virulence are largely unknown. The main purpose of this work was to determine the correlation between known molecular determinants of virulence in different avian influenza virus (AIV) genes and the results of experimental infection of birds and mammals with AIV strain A/swan/Mangistau/3/06 (H5N1; SW/3/06).<h4>Methods and results</h4>We examined the virulence of SW/3/06 in four species of birds (chickens, ducks, turkeys, geese) and five species of mammals (mice, guinea pigs, cats, dogs, pigs), and identified the molecular determinants of virulence in 11 genes (HA, NA, PB1, PB1-F2, PB2, 2014-01-01T00:00:00Z2014 Nov2026-06-07T08:16:40.919Z2025-05-29T19:28:20.378ZS-EPMC42642622547112710.1186/s12985-014-0207-y