{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["211(13)"],"submitter":["Gao P"],"funding":["Intramural NIH HHS"],"pubmed_abstract":["E-proteins are TCR-sensitive transcription factors essential for intrathymic T cell transitions. Here, we show that deletion of E-proteins leads to both enhanced peripheral TGF-β-induced regulatory T (iT reg) cell and thymic naturally arising T reg cell (nT reg cell) differentiation. In contrast, deletion of Id proteins results in reduced nT reg cell differentiation. Mechanistic analysis indicated that decreased E-protein activity leads to de-repression of signaling pathways that are essential to Foxp3 expression. Decreased E-protein binding to an IL-2Rα enhancer locus facilitated TCR-induced IL-2Rα expression. Similarly, decreased E-protein activity facilitated TCR-induced NF-κB activation and generation of c-Rel. Consistent with this, microarray analysis indicated that cells with E-prote"],"journal":["The Journal of experimental medicine"],"pagination":["2651-68"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4267236"],"repository":["biostudies-literature"],"pubmed_title":["Dynamic changes in E-protein activity regulate T reg cell development."],"pmcid":["PMC4267236"],"pubmed_authors":["Zhang F","Yang Z","Gao P","Gardina PJ","Strober W","Fuss IJ","Myers TG","Han X","Zhang Q"],"additional_accession":[]},"is_claimable":false,"name":"Dynamic changes in E-protein activity regulate T reg cell development.","description":"E-proteins are TCR-sensitive transcription factors essential for intrathymic T cell transitions. Here, we show that deletion of E-proteins leads to both enhanced peripheral TGF-β-induced regulatory T (iT reg) cell and thymic naturally arising T reg cell (nT reg cell) differentiation. In contrast, deletion of Id proteins results in reduced nT reg cell differentiation. Mechanistic analysis indicated that decreased E-protein activity leads to de-repression of signaling pathways that are essential to Foxp3 expression. Decreased E-protein binding to an IL-2Rα enhancer locus facilitated TCR-induced IL-2Rα expression. Similarly, decreased E-protein activity facilitated TCR-induced NF-κB activation and generation of c-Rel. Consistent with this, microarray analysis indicated that cells with E-prote","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Dec","modification":"2026-04-29T10:57:48.055Z","creation":"2019-03-27T01:41:46Z"},"accession":"S-EPMC4267236","cross_references":{"pubmed":["25488982"],"doi":["10.1084/jem.20132681"]}}