{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cosgrove KP"],"funding":["NCATS NIH HHS","NIDA NIH HHS","NCRR NIH HHS","NIAAA NIH HHS"],"pagination":["18031-6"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4273348"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["111(50)"],"pubmed_abstract":["Understanding the effects of tobacco smoking on neuroadaptations in GABAA receptor levels over alcohol withdrawal will provide critical insights for the treatment of comorbid alcohol and nicotine dependence. We conducted parallel studies in human subjects and nonhuman primates to investigate the differential effects of tobacco smoking and nicotine on changes in GABAA receptor availability during acute and prolonged alcohol withdrawal. We report that alcohol withdrawal with or without concurrent tobacco smoking/nicotine consumption resulted in significant and robust elevations in GABAA receptor levels over the first week of withdrawal. Over prolonged withdrawal, GABAA receptors returned to control levels in alcohol-dependent nonsmokers, but alcohol-dependent smokers had significant and sust"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal."],"pmcid":["PMC4273348"],"funding_grant_id":["R01AA11321","UL1 TR000142","K02 DA031750","R01 AA017464","UL1 RR024139","P50 AA012870","R01 AA011321","K02DA031750","R01AA17464","P50-AA-12870"],"pubmed_authors":["Bois F","McKay R","Pittman B","Krystal JH","Perkins E","Kloczynski T","Carson RE","O'Malley S","Glahn DC","Cosgrove KP","Esterlis I","Lancaster J"],"additional_accession":[]},"is_claimable":false,"name":"Tobacco smoking interferes with GABAA receptor neuroadaptations during prolonged alcohol withdrawal.","description":"Understanding the effects of tobacco smoking on neuroadaptations in GABAA receptor levels over alcohol withdrawal will provide critical insights for the treatment of comorbid alcohol and nicotine dependence. We conducted parallel studies in human subjects and nonhuman primates to investigate the differential effects of tobacco smoking and nicotine on changes in GABAA receptor availability during acute and prolonged alcohol withdrawal. We report that alcohol withdrawal with or without concurrent tobacco smoking/nicotine consumption resulted in significant and robust elevations in GABAA receptor levels over the first week of withdrawal. Over prolonged withdrawal, GABAA receptors returned to control levels in alcohol-dependent nonsmokers, but alcohol-dependent smokers had significant and sust","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Dec","modification":"2025-04-19T14:40:07.72Z","creation":"2019-03-27T01:42:11Z"},"accession":"S-EPMC4273348","cross_references":{"pubmed":["25453062"],"doi":["10.1073/pnas.1413947111"]}}