{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen P"],"funding":["BLRD VA","NIDDK NIH HHS","NIAAA NIH HHS"],"pagination":["203-214.e16"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4274236"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["148(1)"],"pubmed_abstract":["<h4>Background & aims</h4>Alcoholic liver disease is a leading cause of mortality. Chronic alcohol consumption is accompanied by intestinal dysbiosis, and development of alcoholic liver disease requires gut-derived bacterial products. However, little is known about how alterations to the microbiome contribute to pathogenesis of alcoholic liver disease.<h4>Methods</h4>We used the Tsukamoto-French mouse model, which involves continuous intragastric feeding of isocaloric diet or alcohol for 3 weeks. Bacterial DNA from the cecum was extracted for deep metagenomic sequencing. Targeted metabolomics assessed concentrations of saturated fatty acids in cecal contents. To maintain intestinal metabolic homeostasis, diets of ethanol-fed and control mice were supplemented with saturated long-chain fatt"],"journal":["Gastroenterology"],"pubmed_title":["Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice."],"pmcid":["PMC4274236"],"funding_grant_id":["R01 AA020216","K23 DK090303","R01 AA020203","I01 BX002213","K08 DK081830","U24 DK097153","P50 AA011999","RC2 AA019405","U01 AA021856","R01 AA020703"],"pubmed_authors":["Starkel P","Nelson KE","van Pijkeren JP","Ho SB","Chen P","Torralba M","Tan J","Bajaj JS","Mutlu EA","Embree M","Tsukamoto H","Keshavarzian A","Schnabl B","Fouts DE","DePew J","Loomba R","Zengler K"],"additional_accession":[]},"is_claimable":false,"name":"Supplementation of saturated long-chain fatty acids maintains intestinal eubiosis and reduces ethanol-induced liver injury in mice.","description":"<h4>Background & aims</h4>Alcoholic liver disease is a leading cause of mortality. Chronic alcohol consumption is accompanied by intestinal dysbiosis, and development of alcoholic liver disease requires gut-derived bacterial products. However, little is known about how alterations to the microbiome contribute to pathogenesis of alcoholic liver disease.<h4>Methods</h4>We used the Tsukamoto-French mouse model, which involves continuous intragastric feeding of isocaloric diet or alcohol for 3 weeks. Bacterial DNA from the cecum was extracted for deep metagenomic sequencing. Targeted metabolomics assessed concentrations of saturated fatty acids in cecal contents. To maintain intestinal metabolic homeostasis, diets of ethanol-fed and control mice were supplemented with saturated long-chain fatt","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jan","modification":"2026-06-04T00:39:33.502Z","creation":"2019-03-27T01:42:13Z"},"accession":"S-EPMC4274236","cross_references":{"pubmed":["25239591"],"doi":["10.1053/j.gastro.2014.09.014"]}}