{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5"],"submitter":["Piya S"],"pubmed_abstract":["The phytohormone auxin regulates nearly all aspects of plant growth and development. Based on the current model in Arabidopsis thaliana, Auxin/indole-3-acetic acid (Aux/IAA) proteins repress auxin-inducible genes by inhibiting auxin response transcription factors (ARFs). Experimental evidence suggests that heterodimerization between Aux/IAA and ARF proteins are related to their unique biological functions. The objective of this study was to generate the Aux/IAA-ARF protein-protein interaction map using full length sequences and locate the interacting protein pairs to specific gene co-expression networks in order to define tissue-specific responses of the Aux/IAA-ARF interactome. Pairwise interactions between 19 ARFs and 29 Aux/IAAs resulted in the identification of 213 specific interaction"],"journal":["Frontiers in plant science"],"pagination":["744"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4274898"],"repository":["biostudies-literature"],"pubmed_title":["Protein-protein interaction and gene co-expression maps of ARFs and Aux/IAAs in Arabidopsis."],"pmcid":["PMC4274898"],"pubmed_authors":["Stewart CN","Shrestha SK","Piya S","Hewezi T","Binder B"],"additional_accession":[]},"is_claimable":false,"name":"Protein-protein interaction and gene co-expression maps of ARFs and Aux/IAAs in Arabidopsis.","description":"The phytohormone auxin regulates nearly all aspects of plant growth and development. Based on the current model in Arabidopsis thaliana, Auxin/indole-3-acetic acid (Aux/IAA) proteins repress auxin-inducible genes by inhibiting auxin response transcription factors (ARFs). Experimental evidence suggests that heterodimerization between Aux/IAA and ARF proteins are related to their unique biological functions. The objective of this study was to generate the Aux/IAA-ARF protein-protein interaction map using full length sequences and locate the interacting protein pairs to specific gene co-expression networks in order to define tissue-specific responses of the Aux/IAA-ARF interactome. Pairwise interactions between 19 ARFs and 29 Aux/IAAs resulted in the identification of 213 specific interaction","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014","modification":"2025-04-21T19:50:04.946Z","creation":"2019-03-27T01:42:15Z"},"accession":"S-EPMC4274898","cross_references":{"pubmed":["25566309"],"doi":["10.3389/fpls.2014.00744"]}}