biostudies-literatureUnknown5Piya SThe phytohormone auxin regulates nearly all aspects of plant growth and development. Based on the current model in Arabidopsis thaliana, Auxin/indole-3-acetic acid (Aux/IAA) proteins repress auxin-inducible genes by inhibiting auxin response transcription factors (ARFs). Experimental evidence suggests that heterodimerization between Aux/IAA and ARF proteins are related to their unique biological functions. The objective of this study was to generate the Aux/IAA-ARF protein-protein interaction map using full length sequences and locate the interacting protein pairs to specific gene co-expression networks in order to define tissue-specific responses of the Aux/IAA-ARF interactome. Pairwise interactions between 19 ARFs and 29 Aux/IAAs resulted in the identification of 213 specific interactionFrontiers in plant science744https://www.ebi.ac.uk/biostudies/studies/S-EPMC4274898biostudies-literatureProtein-protein interaction and gene co-expression maps of ARFs and Aux/IAAs in Arabidopsis.PMC4274898Stewart CNShrestha SKPiya SHewezi TBinder BfalseProtein-protein interaction and gene co-expression maps of ARFs and Aux/IAAs in Arabidopsis.The phytohormone auxin regulates nearly all aspects of plant growth and development. Based on the current model in Arabidopsis thaliana, Auxin/indole-3-acetic acid (Aux/IAA) proteins repress auxin-inducible genes by inhibiting auxin response transcription factors (ARFs). Experimental evidence suggests that heterodimerization between Aux/IAA and ARF proteins are related to their unique biological functions. The objective of this study was to generate the Aux/IAA-ARF protein-protein interaction map using full length sequences and locate the interacting protein pairs to specific gene co-expression networks in order to define tissue-specific responses of the Aux/IAA-ARF interactome. Pairwise interactions between 19 ARFs and 29 Aux/IAAs resulted in the identification of 213 specific interaction2014-01-01T00:00:00Z20142025-04-21T19:50:04.946Z2019-03-27T01:42:15ZS-EPMC42748982556630910.3389/fpls.2014.00744