{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Klang IM"],"funding":["NIA NIH HHS","PHS HHS","NIH HHS"],"pagination":["975-91"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4276790"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["6(11)"],"pubmed_abstract":["Many late-onset proteotoxic diseases are accompanied by a disruption in homeostasis of metals (metallostasis) including iron, copper and zinc. Although aging is the most prominent risk factor for these disorders, the impact of aging on metallostasis and its role in proteotoxic disease remain poorly understood. Moreover, it is not clear whether a loss of metallostasis influences normal aging. We have investigated the role of metallostasis in longevity ofCaenorhabditis elegans. We found that calcium, copper, iron, and manganese levels increase as a function of age, while potassium and phosphorus levels tend to decrease. Increased dietary iron significantly accelerated the age-related accumulation of insoluble protein, a molecular pathology of aging. Proteomic analysis revealed widespread eff"],"journal":["Aging"],"pubmed_title":["Iron promotes protein insolubility and aging in C. elegans."],"pmcid":["PMC4276790"],"funding_grant_id":["UL1024917","S10 OD016281","1S10 OD016281","R01 AG045835","1R01AG029631-01A1","R21 AG042053","AG042053-02","R01 AG029631"],"pubmed_authors":["Swoboda P","Lithgow GJ","Sorensen DJ","Kapahi P","Sahu AK","Killilea DW","Klang IM","Gibson BW","Andersen JK","Schilling B"],"additional_accession":[]},"is_claimable":false,"name":"Iron promotes protein insolubility and aging in C. elegans.","description":"Many late-onset proteotoxic diseases are accompanied by a disruption in homeostasis of metals (metallostasis) including iron, copper and zinc. Although aging is the most prominent risk factor for these disorders, the impact of aging on metallostasis and its role in proteotoxic disease remain poorly understood. Moreover, it is not clear whether a loss of metallostasis influences normal aging. We have investigated the role of metallostasis in longevity ofCaenorhabditis elegans. We found that calcium, copper, iron, and manganese levels increase as a function of age, while potassium and phosphorus levels tend to decrease. Increased dietary iron significantly accelerated the age-related accumulation of insoluble protein, a molecular pathology of aging. Proteomic analysis revealed widespread eff","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Nov","modification":"2025-05-29T21:07:22.668Z","creation":"2025-05-29T21:07:22.668Z"},"accession":"S-EPMC4276790","cross_references":{"pubmed":["25554795"],"doi":["10.18632/aging.100689"]}}