{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["1(2)"],"submitter":["Iyoda S"],"pubmed_abstract":["<h4>Background</h4>Enterohemorrhagic Escherichia coli (EHEC) O157:H7 infection causes severe diseases such as bloody diarrhea and hemolytic uremic syndrome (HUS). Although EHEC O157:H7 strains have exhibited high genetic variability, their abilities to cause human diseases have not been fully examined.<h4>Methods</h4>Clade typing and stx subtyping of EHEC O157:H7 strains, which were isolated in Japan during 1999-2011 from 269 HUS patients and 387 asymptomatic carriers (ACs) and showed distinct pulsed-field gel electrophoresis patterns, were performed to determine relationships between specific lineages and clinical presentation.<h4>Results</h4>Clades 6 and 8 strains were more frequently found among the isolates from HUS cases than those from ACs (P = .00062 for clade 6, P < .0001 for clade"],"journal":["Open forum infectious diseases"],"pagination":["ofu061"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4281788"],"repository":["biostudies-literature"],"pubmed_title":["Phylogenetic Clades 6 and 8 of Enterohemorrhagic Escherichia coli O157:H7 With Particular stx Subtypes are More Frequently Found in Isolates From Hemolytic Uremic Syndrome Patients Than From Asymptomatic Carriers."],"pmcid":["PMC4281788"],"pubmed_authors":["Chiba K","Kubota T","Terajima J","Kikuchi K","Kobayashi H","Iguchi A","Kasahara H","Takashi K","Ueno H","Kimata K","Izumiya H","Asoshima N","Ogata K","Hiroi M","Tominaga K","Takamura M","Nakajima H","Kawano K","Nakamura H","Iwabuchi K","Morita-Ishihara T","Kurazono T","Sakamoto Y","Asano Y","Kojima Y","Hatakeyama T","Isobe J","Nishi K","Seto K","Hamada M","Ichihara S","Kitahashi T","Furukawa I","Horikawa K","Asai N","Satoh H","Konishi N","Tokoi Y","Ogura Y","Nagai Y","Kuroki T","Hirochi T","Ohnishi M","Saitoh E","Kudaka J","Kawanishi S","Kai A","Tanaka K","Yatsuyanagi J","Manning SD","Iyoda S","Naitoh H","Saitoh T","Harada S","Matsumoto Y","Migita Y","Kawase M","Shiraki Y","Kono T","Nakane K","Yabata J","Etoh Y","Arai R","Tanabe J","Honda M","Hara-Kudo Y","Obata H","Matsumoto K","Kameyama M","Matsumoto M"],"additional_accession":[]},"is_claimable":false,"name":"Phylogenetic Clades 6 and 8 of Enterohemorrhagic Escherichia coli O157:H7 With Particular stx Subtypes are More Frequently Found in Isolates From Hemolytic Uremic Syndrome Patients Than From Asymptomatic Carriers.","description":"<h4>Background</h4>Enterohemorrhagic Escherichia coli (EHEC) O157:H7 infection causes severe diseases such as bloody diarrhea and hemolytic uremic syndrome (HUS). Although EHEC O157:H7 strains have exhibited high genetic variability, their abilities to cause human diseases have not been fully examined.<h4>Methods</h4>Clade typing and stx subtyping of EHEC O157:H7 strains, which were isolated in Japan during 1999-2011 from 269 HUS patients and 387 asymptomatic carriers (ACs) and showed distinct pulsed-field gel electrophoresis patterns, were performed to determine relationships between specific lineages and clinical presentation.<h4>Results</h4>Clades 6 and 8 strains were more frequently found among the isolates from HUS cases than those from ACs (P = .00062 for clade 6, P < .0001 for clade","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Sep","modification":"2025-04-04T23:51:59.945Z","creation":"2019-06-06T13:41:11Z"},"accession":"S-EPMC4281788","cross_references":{"pubmed":["25734131"],"doi":["10.1093/ofid/ofu061"]}}