biostudies-literatureUnknown1(2)Iyoda S<h4>Background</h4>Enterohemorrhagic Escherichia coli (EHEC) O157:H7 infection causes severe diseases such as bloody diarrhea and hemolytic uremic syndrome (HUS). Although EHEC O157:H7 strains have exhibited high genetic variability, their abilities to cause human diseases have not been fully examined.<h4>Methods</h4>Clade typing and stx subtyping of EHEC O157:H7 strains, which were isolated in Japan during 1999-2011 from 269 HUS patients and 387 asymptomatic carriers (ACs) and showed distinct pulsed-field gel electrophoresis patterns, were performed to determine relationships between specific lineages and clinical presentation.<h4>Results</h4>Clades 6 and 8 strains were more frequently found among the isolates from HUS cases than those from ACs (P = .00062 for clade 6, P < .0001 for cladeOpen forum infectious diseasesofu061https://www.ebi.ac.uk/biostudies/studies/S-EPMC4281788biostudies-literaturePhylogenetic Clades 6 and 8 of Enterohemorrhagic Escherichia coli O157:H7 With Particular stx Subtypes are More Frequently Found in Isolates From Hemolytic Uremic Syndrome Patients Than From Asymptomatic Carriers.PMC4281788Chiba KKubota TTerajima JKikuchi KKobayashi HIguchi AKasahara HTakashi KUeno HKimata KIzumiya HAsoshima NOgata KHiroi MTominaga KTakamura MNakajima HKawano KNakamura HIwabuchi KMorita-Ishihara TKurazono TSakamoto YAsano YKojima YHatakeyama TIsobe JNishi KSeto KHamada MIchihara SKitahashi TFurukawa IHorikawa KAsai NSatoh HKonishi NTokoi YOgura YNagai YKuroki THirochi TOhnishi MSaitoh EKudaka JKawanishi SKai ATanaka KYatsuyanagi JManning SDIyoda SNaitoh HSaitoh THarada SMatsumoto YMigita YKawase MShiraki YKono TNakane KYabata JEtoh YArai RTanabe JHonda MHara-Kudo YObata HMatsumoto KKameyama MMatsumoto MfalsePhylogenetic Clades 6 and 8 of Enterohemorrhagic Escherichia coli O157:H7 With Particular stx Subtypes are More Frequently Found in Isolates From Hemolytic Uremic Syndrome Patients Than From Asymptomatic Carriers.<h4>Background</h4>Enterohemorrhagic Escherichia coli (EHEC) O157:H7 infection causes severe diseases such as bloody diarrhea and hemolytic uremic syndrome (HUS). Although EHEC O157:H7 strains have exhibited high genetic variability, their abilities to cause human diseases have not been fully examined.<h4>Methods</h4>Clade typing and stx subtyping of EHEC O157:H7 strains, which were isolated in Japan during 1999-2011 from 269 HUS patients and 387 asymptomatic carriers (ACs) and showed distinct pulsed-field gel electrophoresis patterns, were performed to determine relationships between specific lineages and clinical presentation.<h4>Results</h4>Clades 6 and 8 strains were more frequently found among the isolates from HUS cases than those from ACs (P = .00062 for clade 6, P < .0001 for clade2014-01-01T00:00:00Z2014 Sep2025-04-04T23:51:59.945Z2019-06-06T13:41:11ZS-EPMC42817882573413110.1093/ofid/ofu061