{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McClure CD"],"funding":["Scottish Funding Council","Department for Environment, Food and Rural Affairs","University of Bath","Natural Environment Research Council","Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["2225-33"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4282086"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["68(8)"],"pubmed_abstract":["Many have argued that we may be able to extend life and improve human health through hormesis, the beneficial effects of low-level toxins and other stressors. But, studies of hormesis in model systems have not yet established whether stress-induced benefits are cost free, artifacts of inbreeding, or come with deleterious side effects. Here, we provide evidence that hormesis results in trade-offs with immunity. We find that a single topical dose of dead spores of the entomopathogenic fungus, Metarhizium robertsii, increases the longevity of the fruit fly, Drosophila melanogaster, without significant decreases in fecundity. We find that hormetic benefits of pathogen challenge are greater in lines that lack key components of antifungal immunity (Dif and Turandot M). And, in outbred fly lines,"],"journal":["Evolution; international journal of organic evolution"],"pubmed_title":["Hormesis results in trade-offs with immunity."],"pmcid":["PMC4282086"],"funding_grant_id":["BB/I000801/1","BB/I000836/1"],"pubmed_authors":["McClure CD","Priest NK","Hunt VL","Zhong W","Chapman FM","Hill FV"],"additional_accession":[]},"is_claimable":false,"name":"Hormesis results in trade-offs with immunity.","description":"Many have argued that we may be able to extend life and improve human health through hormesis, the beneficial effects of low-level toxins and other stressors. But, studies of hormesis in model systems have not yet established whether stress-induced benefits are cost free, artifacts of inbreeding, or come with deleterious side effects. Here, we provide evidence that hormesis results in trade-offs with immunity. We find that a single topical dose of dead spores of the entomopathogenic fungus, Metarhizium robertsii, increases the longevity of the fruit fly, Drosophila melanogaster, without significant decreases in fecundity. We find that hormetic benefits of pathogen challenge are greater in lines that lack key components of antifungal immunity (Dif and Turandot M). And, in outbred fly lines,","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Aug","modification":"2025-04-26T02:45:45.286Z","creation":"2019-03-27T01:42:36Z"},"accession":"S-EPMC4282086","cross_references":{"pubmed":["24862588"],"doi":["10.1111/evo.12453"]}}