biostudies-literatureThompson PNCI NIH HHSNIGMS NIH HHS831-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC4282931biostudies-literatureUnknown74(4)<h4>Purpose</h4>We explored the impact of obesity, body composition, and genetic polymorphisms on the pharmacokinetics (PK) of daunorubicin in children with cancer.<h4>Patients and methods</h4>Patients ≤21 years receiving daunorubicin as an infusion of any duration <24 h for any type of cancer were eligible. Plasma drug concentrations were measured by high-performance liquid chromatography. Body composition was measured by dual-energy X-ray absorptiometry. Obesity was defined as a BMI >95% for age or as body fat >30%. NONMEM was used to perform PK model fitting. The Affymetrix DMET chip was used for genotyping. The impact of genetic polymorphisms was investigated using SNP/haplotype association analysis with estimated individual PK parameters.<h4>Results</h4>A total of 107 subjects were enCancer chemotherapy and pharmacologyPharmacokinetics and pharmacogenomics of daunorubicin in children: a report from the Children's Oncology Group.PMC4282931U10 CA098543UG1 CA189955GM61393U10 CA180886U01 GM061393F32CA165823F32 CA165823U10 CA180899U10 CA095861U10 CA098413Devidas MSung LDolan METhompson PLorier RDelaney SMWheeler HEBroeckel UBerg SLReaman GHScorsone KfalsePharmacokinetics and pharmacogenomics of daunorubicin in children: a report from the Children's Oncology Group.<h4>Purpose</h4>We explored the impact of obesity, body composition, and genetic polymorphisms on the pharmacokinetics (PK) of daunorubicin in children with cancer.<h4>Patients and methods</h4>Patients ≤21 years receiving daunorubicin as an infusion of any duration <24 h for any type of cancer were eligible. Plasma drug concentrations were measured by high-performance liquid chromatography. Body composition was measured by dual-energy X-ray absorptiometry. Obesity was defined as a BMI >95% for age or as body fat >30%. NONMEM was used to perform PK model fitting. The Affymetrix DMET chip was used for genotyping. The impact of genetic polymorphisms was investigated using SNP/haplotype association analysis with estimated individual PK parameters.<h4>Results</h4>A total of 107 subjects were en2014-01-01T00:00:00Z2014 Oct2026-04-29T12:13:32.095Z2019-03-27T01:42:40ZS-EPMC42829312511918210.1007/s00280-014-2535-4