{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gupta R"],"funding":["NIAMS NIH HHS"],"pagination":["61-78"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4285384"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(1)"],"pubmed_abstract":["Psoriasis is a chronic, inflammatory, immune-mediated skin condition with a prevalence of 0-11.8% across the world. It is associated with a number of cardiovascular, metabolic, and autoimmune disease co-morbidities. Psoriasis is a multifactorial disorder, influenced by both genetic and environmental factors. Its genetic basis has long been established through twin studies and familial clustering. The association of psoriasis with the HLA-Cw6 allele has been shown in many studies. Recent genome-wide association studies have identified a large number of other genes associated with psoriasis. Many of these genes regulate the innate and adaptive immune system. These findings indicate that a dysregulated immune system may play a major role in the pathogenesis of psoriasis. In this article, we review the clinical and genetic epidemiology of psoriasis with a brief description of the pathogenesis of disease."],"journal":["Current dermatology reports"],"pubmed_title":["Genetic Epidemiology of Psoriasis."],"pmcid":["PMC4285384"],"funding_grant_id":["K08 AR057763","R01 AR065174"],"pubmed_authors":["Gupta R","Debbaneh MG","Liao W"],"additional_accession":[]},"is_claimable":false,"name":"Genetic Epidemiology of Psoriasis.","description":"Psoriasis is a chronic, inflammatory, immune-mediated skin condition with a prevalence of 0-11.8% across the world. It is associated with a number of cardiovascular, metabolic, and autoimmune disease co-morbidities. Psoriasis is a multifactorial disorder, influenced by both genetic and environmental factors. Its genetic basis has long been established through twin studies and familial clustering. The association of psoriasis with the HLA-Cw6 allele has been shown in many studies. Recent genome-wide association studies have identified a large number of other genes associated with psoriasis. Many of these genes regulate the innate and adaptive immune system. These findings indicate that a dysregulated immune system may play a major role in the pathogenesis of psoriasis. In this article, we review the clinical and genetic epidemiology of psoriasis with a brief description of the pathogenesis of disease.","dates":{"release":"2014-01-01T00:00:00Z","publication":"2014 Mar","modification":"2024-11-09T10:55:34.476Z","creation":"2019-03-27T01:42:49Z"},"accession":"S-EPMC4285384","cross_references":{"pubmed":["25580373"],"doi":["10.1007/s13671-013-0066-6"]}}