{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Piccirillo SG"],"funding":["Cancer Research UK","Medical Research Council","National Institute for Health Research (NIHR)","The Brain Tumour Charity","Wellcome Trust"],"pagination":["194-202"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4286248"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["75(1)"],"pubmed_abstract":["Glioblastoma, the most common and aggressive adult brain tumor, is characterized by extreme phenotypic diversity and treatment failure. Through fluorescence-guided resection, we identified fluorescent tissue in the sub-ependymal zone (SEZ) of patients with glioblastoma. Histologic analysis and genomic characterization revealed that the SEZ harbors malignant cells with tumor-initiating capacity, analogous to cells isolated from the fluorescent tumor mass (T). We observed resistance to supramaximal chemotherapy doses along with differential patterns of drug response between T and SEZ in the same tumor. Our results reveal novel insights into glioblastoma growth dynamics, with implications for understanding and limiting treatment resistance."],"journal":["Cancer research"],"pubmed_title":["Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone."],"pmcid":["PMC4286248"],"funding_grant_id":["C1023/A14545","19556","G1001522","NIHR/CS/009/011","A14545","090340","MC_UU_12022/1","A10825","C14303/A10825","MC_UU_12022/8","10/136","16700","14545"],"pubmed_authors":["Venkitaraman AR","Spiteri I","Curtis C","Collins VP","Piccirillo SG","Watts C","Francis NJ","Ber S","Heywood R","Howarth KD","Touloumis A","Sottoriva A","Tavare S","Marioni JC","Price SJ"],"additional_accession":[]},"is_claimable":false,"name":"Contributions to drug resistance in glioblastoma derived from malignant cells in the sub-ependymal zone.","description":"Glioblastoma, the most common and aggressive adult brain tumor, is characterized by extreme phenotypic diversity and treatment failure. Through fluorescence-guided resection, we identified fluorescent tissue in the sub-ependymal zone (SEZ) of patients with glioblastoma. Histologic analysis and genomic characterization revealed that the SEZ harbors malignant cells with tumor-initiating capacity, analogous to cells isolated from the fluorescent tumor mass (T). We observed resistance to supramaximal chemotherapy doses along with differential patterns of drug response between T and SEZ in the same tumor. Our results reveal novel insights into glioblastoma growth dynamics, with implications for understanding and limiting treatment resistance.","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jan","modification":"2026-04-29T12:28:11.869Z","creation":"2019-03-27T01:42:53Z"},"accession":"S-EPMC4286248","cross_references":{"pubmed":["25406193"],"doi":["10.1158/0008-5472.can-13-3131","10.1158/0008-5472.CAN-13-3131"]}}