{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang B"],"funding":["NCI NIH HHS"],"pagination":["564-70"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4289616"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["119(3)"],"pubmed_abstract":["<h4>Objective</h4>To assess the role of active immunotherapy targeting VEGF with a peptide vaccine as a potential treatment for ovarian cancer.<h4>Methods</h4>A peptide vaccine targeting antigenic B-cell epitopes of VEGF were identified and linked to a promiscuous T-cell epitope. Elicited antibodies were assessed for their ability to recognize the VEGF protein, inhibit angiogenesis, inhibit the interaction of VEGF with its receptor, and inhibit cancer growth in mice.<h4>Results</h4>Following immunization, high-titered elicited antibodies were shown to be specific for the full-length VEGF protein by ELISA and Western blot. Anti-VEGF peptide antibodies inhibited cellular migration, proliferation, invasion, tube formation, and growth of aortic ring cultures. These antibodies inhibited the int"],"journal":["Gynecologic oncology"],"pubmed_title":["Immunization with synthetic VEGF peptides in ovarian cancer."],"pmcid":["PMC4289616"],"funding_grant_id":["P30 CA016058"],"pubmed_authors":["Wang B","Kaumaya PT","Cohn DE"],"additional_accession":[]},"is_claimable":false,"name":"Immunization with synthetic VEGF peptides in ovarian cancer.","description":"<h4>Objective</h4>To assess the role of active immunotherapy targeting VEGF with a peptide vaccine as a potential treatment for ovarian cancer.<h4>Methods</h4>A peptide vaccine targeting antigenic B-cell epitopes of VEGF were identified and linked to a promiscuous T-cell epitope. Elicited antibodies were assessed for their ability to recognize the VEGF protein, inhibit angiogenesis, inhibit the interaction of VEGF with its receptor, and inhibit cancer growth in mice.<h4>Results</h4>Following immunization, high-titered elicited antibodies were shown to be specific for the full-length VEGF protein by ELISA and Western blot. Anti-VEGF peptide antibodies inhibited cellular migration, proliferation, invasion, tube formation, and growth of aortic ring cultures. These antibodies inhibited the int","dates":{"release":"2010-01-01T00:00:00Z","publication":"2010 Dec","modification":"2025-06-27T03:05:41.082Z","creation":"2025-06-27T03:05:41.082Z"},"accession":"S-EPMC4289616","cross_references":{"pubmed":["20822802"],"doi":["10.1016/j.ygyno.2010.07.037"]}}