biostudies-literatureFontana RJMichigan Institute for Clinical and Health ResearchNIDDK Training GrantNIDDK NIH HHSTips Fund of Northwestern Medical FoundationJeanne Roberts and Rollin and Mary Ella King Funds of the Southwestern Medical FoundationNational Institute of Diabetes, Digestive and Kidney Diseases370-80https://www.ebi.ac.uk/biostudies/studies/S-EPMC4291312biostudies-literatureUnknown35(2)<h4>Background & aims</h4>The long-term clinical outcomes in initial survivors with acute liver failure (ALF) are not well known. The aim of this study was to provide an overview of the 2-year clinical outcomes among initial survivors and liver transplant (LT) recipients that were alive 3 weeks after enrolment in the Acute Liver Failure Study Group (ALFSG).<h4>Methods</h4>Outcomes in adult ALFSG patients that were enrolled between 1998 and 2010 were reviewed.<h4>Results</h4>Two-year patient survival was significantly higher in the 262 LT recipients (92.4%) compared to the 306 acetaminophen (APAP) spontaneous survivors (SS) (89.5%) and 200 non-APAP SS (75.5%) (P < 0.0001). The causes of death were similar in the three groups but the time to death was significantly longer in the LT recipientLiver international : official journal of the International Association for the Study of the LiverTwo-year outcomes in initial survivors with acute liver failure: results from a prospective, multicentre study.PMC4291312T32 DK62708-01DK U-01-58369T32 DK062708DK62708-01U01 DK058369Reddy RKLiou ILalani ELarson AMGoddard TGanger DHan SHDillon CMcGuire BShaikh AReuben APezzia CMurray MMurray NChung RTMcCashland THassanein TFontana RJDurkalski VPolson JMunoz SRangnekar AHay JEZaman AReddy RSatyanarayana RFontana RSanders COstapowicz GAEllerbe CZhao WUS Acute Liver Failure Study GroupHan SSchiodt FVGanger DRDavern THarrison ESchilsky MAttar NReisch JSCrippin JWebster JWLee WMSmith ARossaro LSmith JPBlei AFix OStravitz TStravitz RHynan LSSamuel GDurkalski VEBrown RfalseTwo-year outcomes in initial survivors with acute liver failure: results from a prospective, multicentre study.<h4>Background & aims</h4>The long-term clinical outcomes in initial survivors with acute liver failure (ALF) are not well known. The aim of this study was to provide an overview of the 2-year clinical outcomes among initial survivors and liver transplant (LT) recipients that were alive 3 weeks after enrolment in the Acute Liver Failure Study Group (ALFSG).<h4>Methods</h4>Outcomes in adult ALFSG patients that were enrolled between 1998 and 2010 were reviewed.<h4>Results</h4>Two-year patient survival was significantly higher in the 262 LT recipients (92.4%) compared to the 306 acetaminophen (APAP) spontaneous survivors (SS) (89.5%) and 200 non-APAP SS (75.5%) (P < 0.0001). The causes of death were similar in the three groups but the time to death was significantly longer in the LT recipient2015-01-01T00:00:00Z2015 Feb2025-04-27T19:36:22.518Z2019-03-27T01:43:16ZS-EPMC42913122503993010.1111/liv.12632