{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cencer M"],"funding":["U.S. Environmental Protection Agency","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["404-10"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4294588"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["Dopamine mimics the exceptional moisture-resistant adhesive properties of the amino acid, DOPA, found in adhesive proteins secreted by marine mussels. The catechol side chain of dopamine was functionalized with a nitro-group, and the effect of the electron withdrawing group modification on the cross-linking chemistry and bioadhesive properties of the adhesive moiety was evaluated. Both nitrodopamine and dopamine were covalently attached as a terminal group onto an inert, 4-armed poly(ethylene glygol) (PEG-ND and PEG-D, respectively). PEG-ND and PEG-D exhibited different dependence on the concentration of NaIO4 and pH, which affected the curing rate, mechanical properties, and adhesive performance of these biomimetic adhesives differently. PEG-ND cured instantly and its bioadhesive properti"],"journal":["Biomacromolecules"],"pubmed_title":["Effect of nitro-functionalization on the cross-linking and bioadhesion of biomimetic adhesive moiety."],"pmcid":["PMC4294588"],"funding_grant_id":["GM104846","R15 GM104846","R15GM104846"],"pubmed_authors":["Liu Y","Cencer M","Murley M","Lee BP"],"additional_accession":[]},"is_claimable":false,"name":"Effect of nitro-functionalization on the cross-linking and bioadhesion of biomimetic adhesive moiety.","description":"Dopamine mimics the exceptional moisture-resistant adhesive properties of the amino acid, DOPA, found in adhesive proteins secreted by marine mussels. The catechol side chain of dopamine was functionalized with a nitro-group, and the effect of the electron withdrawing group modification on the cross-linking chemistry and bioadhesive properties of the adhesive moiety was evaluated. Both nitrodopamine and dopamine were covalently attached as a terminal group onto an inert, 4-armed poly(ethylene glygol) (PEG-ND and PEG-D, respectively). PEG-ND and PEG-D exhibited different dependence on the concentration of NaIO4 and pH, which affected the curing rate, mechanical properties, and adhesive performance of these biomimetic adhesives differently. PEG-ND cured instantly and its bioadhesive properti","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jan","modification":"2025-05-29T21:22:17.74Z","creation":"2025-05-29T21:22:17.74Z"},"accession":"S-EPMC4294588","cross_references":{"pubmed":["25495043"],"doi":["10.1021/bm5016333"]}}