{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bansal A"],"funding":["NIA NIH HHS","NIH HHS"],"pagination":["E277-86"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4311797"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["112(3)"],"pubmed_abstract":["Aging research has been very successful at identifying signaling pathways and evolutionarily conserved genes that extend lifespan with the assumption that an increase in lifespan will also increase healthspan. However, it is largely unknown whether we are extending the healthy time of life or simply prolonging a period of frailty with increased incidence of age-associated diseases. Here we use Caenorhabditis elegans, one of the premiere systems for lifespan studies, to determine whether lifespan and healthspan are intrinsically correlated. We conducted multiple cellular and organismal assays on wild type as well as four long-lived mutants (insulin/insulin-like growth factor-1, dietary restriction, protein translation, mitochondrial signaling) in a longitudinal manner to determine the healt"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants."],"pmcid":["PMC4311797"],"funding_grant_id":["AG025891","P40 OD010440","R01 AG025891"],"pubmed_authors":["Bansal A","Zhu LJ","Tissenbaum HA","Yen K"],"additional_accession":[]},"is_claimable":false,"name":"Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants.","description":"Aging research has been very successful at identifying signaling pathways and evolutionarily conserved genes that extend lifespan with the assumption that an increase in lifespan will also increase healthspan. However, it is largely unknown whether we are extending the healthy time of life or simply prolonging a period of frailty with increased incidence of age-associated diseases. Here we use Caenorhabditis elegans, one of the premiere systems for lifespan studies, to determine whether lifespan and healthspan are intrinsically correlated. We conducted multiple cellular and organismal assays on wild type as well as four long-lived mutants (insulin/insulin-like growth factor-1, dietary restriction, protein translation, mitochondrial signaling) in a longitudinal manner to determine the healt","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jan","modification":"2026-04-29T14:26:42.434Z","creation":"2026-04-07T15:19:53.801Z"},"accession":"S-EPMC4311797","cross_references":{"pubmed":["25561524"],"doi":["10.1073/pnas.1412192112"]}}