{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["HHS | National Institutes of Health","NHLBI NIH HHS","NIGMS NIH HHS"],"pagination":["1226-31"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC4313810"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["112(4)"],"pubmed_abstract":["Plasma growth hormone (GH) and hepatic autophagy each have been reported to protect against hypoglycemia in the fasted state, but previous data have not linked the two. Here we demonstrate a connection using a mouse model of fasting in a fat-depleted state. Mice were subjected to 1 wk of 60% calorie restriction, causing them to lose nearly all body fat. They were then fasted for 23 h. During fasting, WT mice developed massive increases in plasma GH and a concomitant increase in hepatic autophagy, allowing them to maintain viable levels of blood glucose. In contrast, lethal hypoglycemia occurred in mice deficient in the GH secretagogue ghrelin as a result of knockout of the gene encoding ghrelin O-acyltransferase (GOAT), which catalyzes a required acylation of the peptide. Fasting fat-deple"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: reversal by growth hormone."],"pmcid":["PMC4313810"],"funding_grant_id":["HL20948","T32 GM008014","P01 HL020948","ST32GM08014"],"pubmed_authors":["Zhang Y","Fang F","Zhao TJ","Goldstein JL","Brown MS"],"additional_accession":[]},"is_claimable":false,"name":"Reduced autophagy in livers of fasted, fat-depleted, ghrelin-deficient mice: reversal by growth hormone.","description":"Plasma growth hormone (GH) and hepatic autophagy each have been reported to protect against hypoglycemia in the fasted state, but previous data have not linked the two. Here we demonstrate a connection using a mouse model of fasting in a fat-depleted state. Mice were subjected to 1 wk of 60% calorie restriction, causing them to lose nearly all body fat. They were then fasted for 23 h. During fasting, WT mice developed massive increases in plasma GH and a concomitant increase in hepatic autophagy, allowing them to maintain viable levels of blood glucose. In contrast, lethal hypoglycemia occurred in mice deficient in the GH secretagogue ghrelin as a result of knockout of the gene encoding ghrelin O-acyltransferase (GOAT), which catalyzes a required acylation of the peptide. Fasting fat-deple","dates":{"release":"2015-01-01T00:00:00Z","publication":"2015 Jan","modification":"2025-04-21T19:48:33.71Z","creation":"2019-03-27T01:44:25Z"},"accession":"S-EPMC4313810","cross_references":{"pubmed":["25583513"],"doi":["10.1073/pnas.1423643112"]}}