biostudies-literatureHudson MMNCI NIH HHS479-91https://www.ebi.ac.uk/biostudies/studies/S-EPMC4314595biostudies-literatureUnknown33(5)<h4>Purpose</h4>To compare age-dependent changes in health status among childhood cancer survivors and a sibling cohort.<h4>Methods</h4>Adult survivors of childhood cancer and siblings, all participants of the Childhood Cancer Survivor Study, completed three surveys assessing health status. At each of three time points, participants were classified as having poor outcomes in general health, mental health, function, or daily activities if they indicated moderate to extreme impairment. Generalized linear mixed models were used to compare survivors with siblings for each outcome as a function of age and to identify host- and treatment-related factors associated with age-dependent worsening health status.<h4>Results</h4>Adverse health status outcomes were more frequent among survivors than sibJournal of clinical oncology : official journal of the American Society of Clinical OncologyAge-dependent changes in health status in the Childhood Cancer Survivor cohort.PMC4314595P30 CA021765U24 CA055727CA21765CA55727Ness KKHudson MMRobison LLLeisenring WKrull KRMulrooney DABrinkman TMJones KMertens ACasillas JGurney JGOeffinger KCCastellino SMNathan PCfalseAge-dependent changes in health status in the Childhood Cancer Survivor cohort.<h4>Purpose</h4>To compare age-dependent changes in health status among childhood cancer survivors and a sibling cohort.<h4>Methods</h4>Adult survivors of childhood cancer and siblings, all participants of the Childhood Cancer Survivor Study, completed three surveys assessing health status. At each of three time points, participants were classified as having poor outcomes in general health, mental health, function, or daily activities if they indicated moderate to extreme impairment. Generalized linear mixed models were used to compare survivors with siblings for each outcome as a function of age and to identify host- and treatment-related factors associated with age-dependent worsening health status.<h4>Results</h4>Adverse health status outcomes were more frequent among survivors than sib2015-01-01T00:00:00Z2015 Feb2025-04-26T00:16:56.161Z2019-03-27T01:44:29ZS-EPMC43145952554751010.1200/JCO.2014.57.486310.1200/jco.2014.57.4863