biostudies-literatureRautanen AThuringian Ministry of EducationWellcome Trust grant referenceEuropean Research CouncilWellcome Trust Core Award Grant NumberMedical Research CouncilNational Institute for Health Research (NIHR)Wellcome TrustFederal Ministry of Education and Research53-60https://www.ebi.ac.uk/biostudies/studies/S-EPMC4314768biostudies-literatureUnknown3(1)<h4>Background</h4>Sepsis continues to be a major cause of death, disability, and health-care expenditure worldwide. Despite evidence suggesting that host genetics can influence sepsis outcomes, no specific loci have yet been convincingly replicated. The aim of this study was to identify genetic variants that influence sepsis survival.<h4>Methods</h4>We did a genome-wide association study in three independent cohorts of white adult patients admitted to intensive care units with sepsis, severe sepsis, or septic shock (as defined by the International Consensus Criteria) due to pneumonia or intra-abdominal infection (cohorts 1-3, n=2534 patients). The primary outcome was 28 day survival. Results for the cohort of patients with sepsis due to pneumonia were combined in a meta-analysis of 1553 pThe Lancet. Respiratory medicineGenome-wide association study of survival from sepsis due to pneumonia: an observational cohort study.PMC4314768ACF-2011-13-0040312617CL-2006-13-003294557G1100449NIHR/CS/009/007B309-00014G9521010NF-SI-0514-10158NF-SI-0512-10113G0900747MR/K006584/1G1001712090532/Z/09/Z090532/Z/09/Z and MRC Hub grant G0900747 91070Sirgo GGarrard CSSchneider EMHill AVRussell JAChapman SJCotogni PReinhart KHolloway PARautanen AChiche JDRusswurm SMeitinger TRello JGordon ACMills TCWeiss YGKnight JCNuamah RElliott KSMein CSteffens MHinds CJESICM/ECCRN GenOSept InvestigatorsSarapuu SHutton PBion JParks TCaulfield MJStuber FDavenport EEWalley KRWienker TFRanieri VMLichtner PBloos FKobilay MSramek VBobek IfalseGenome-wide association study of survival from sepsis due to pneumonia: an observational cohort study.<h4>Background</h4>Sepsis continues to be a major cause of death, disability, and health-care expenditure worldwide. Despite evidence suggesting that host genetics can influence sepsis outcomes, no specific loci have yet been convincingly replicated. The aim of this study was to identify genetic variants that influence sepsis survival.<h4>Methods</h4>We did a genome-wide association study in three independent cohorts of white adult patients admitted to intensive care units with sepsis, severe sepsis, or septic shock (as defined by the International Consensus Criteria) due to pneumonia or intra-abdominal infection (cohorts 1-3, n=2534 patients). The primary outcome was 28 day survival. Results for the cohort of patients with sepsis due to pneumonia were combined in a meta-analysis of 1553 p2015-01-01T00:00:00Z2015 Jan2026-04-30T23:37:31.893Z2019-03-27T01:44:30ZS-EPMC43147682553349110.1016/S2213-2600(14)70290-5